ENSMUSG00000067336


Mus musculus

Features
Gene ID: ENSMUSG00000067336
  
Biological name :Bmpr2
  
Synonyms : Bmpr2 / Bone morphotic protein receptor type-2 / O35607
  
Possible biological names infered from orthology : bone morphogenetic protein receptor type 2 / Q13873
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 59763400
Gene end: 59879014
  
Corresponding Affymetrix probe sets: 10346651 (MoGene1.0st)   1419616_at (Mouse Genome 430 2.0 Array)   1434310_at (Mouse Genome 430 2.0 Array)   1441652_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084701
NCBI entrez gene - 12168     See in Manteia.
MGI - MGI:1095407
RefSeq - NM_007561
RefSeq - XM_006495633
RefSeq Peptide - NP_031587
swissprot - O35607
Ensembl - ENSMUSG00000067336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmpr2aENSDARG00000011941Danio rerio
 bmpr2bENSDARG00000020057Danio rerio
 BMPR2ENSGALG00000008459Gallus gallus
 BMPR2ENSG00000204217Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amhr2 / Q8K592 / Mus musculus anti-Mullerian hormone type 2 receptor (Amhr2), transcript variant 2, mRNA. / Q16671* / anti-Mullerian hormone receptor type 2*ENSMUSG0000002304718
Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*ENSMUSG0000006139317
Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*ENSMUSG0000005215517
Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*ENSMUSG0000003244015
Acvr1 / P37172 / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA. / Q04771* / activin A receptor type 1*ENSMUSG0000002683614
Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*ENSMUSG0000005243013
Acvr1c / Q8K348 / Activin receptor type-1C / Q8NER5* / activin A receptor type 1C*ENSMUSG0000002683413
Acvr1b / Q61271 / Activin receptor type-1B / P36896* / activin A receptor type 1B*ENSMUSG0000000053213
Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*ENSMUSG0000002179613
Acvrl1 / Q61288 / Serine/threonine-protein kinase receptor R3 / P37023* / activin A receptor like type 1*ENSMUSG0000000053013
Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*ENSMUSG0000000761313


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015770  Bone morphogenetic protein receptor type-2
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IMP
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002063 chondrocyte development IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0003183 mitral valve morphogenesis IMP
 biological_processGO:0003186 tricuspid valve morphogenesis IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway ISO
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0014916 regulation of lung blood pressure IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030166 proteoglycan biosynthetic process ISS
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:0045906 negative regulation of vasoconstriction IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IMP
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0060173 limb development IGI
 biological_processGO:0060350 endochondral bone morphogenesis ISS
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0060836 lymphatic endothelial cell differentiation IMP
 biological_processGO:0060840 artery development IMP
 biological_processGO:0060841 venous blood vessel development IMP
 biological_processGO:0061036 positive regulation of cartilage development ISS
 biological_processGO:0061298 retina vasculature development in camera-type eye IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:1902731 negative regulation of chondrocyte proliferation IEA
 biological_processGO:1905314 semi-lunar valve development IMP
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098821 BMP receptor activity IMP


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr2tm1Mmue/Bmpr2+,Smad1tm1Rjle/Smad1+
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmpr2tm1Mmue/Bmpr2+
Genetic Background: B6.129S1-Bmpr2tm1Mmue

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

Allelic Composition: Bmpr2tm1.1Enl/Bmpr2tm1.1Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Phf13Gt(XB691)Byg/Phf13Gt(XB691)Byg
Genetic Background: B6.129P2-Phf13Gt(XB691)Byg

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Tyk2tm1Biat/Tyk2tm1Biat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003034 increased pulmonary vascular resistance "greater than the normal force opposing blood flow in the lung blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Phf13Gt(XB691)Byg/Phf13Gt(XB691)Byg
Genetic Background: B6.129P2-Phf13Gt(XB691)Byg

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr2tm1Mmue/Bmpr2+
Genetic Background: B6.129S1-Bmpr2tm1Mmue

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Bmpr2tm1Mmue/Bmpr2+
Genetic Background: B6.129S1-Bmpr2tm1Mmue

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004012 increased pulmonary artery pressure "increased pulmonary pressure compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006134 arterial occlusion "blockage of blood flow through one or more arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hes1tm1Fgu/Hes1tm1Fgu,Hes3tm1Kag/Hes3tm1Kag
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0009798 abnormal ophthalmic nerve morphology "any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr2tm1.1Enl/Bmpr2tm1.2Enl,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmpr2tm1Mmue/Bmpr2+
Genetic Background: B6.129S1-Bmpr2tm1Mmue

Allelic Composition: Bmpr2tm1Mmue/Bmpr2+,Smad1tm1Rjle/Smad1+
Genetic Background: involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Dxmod/Dxmod,Prkdcdxnph/Prkdcdxnph
Genetic Background: involves: BALB/cJ * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Rnf165Gt(P9-3F)Sor/Rnf165+,Tg(Hlxb9-GFP)1Tmj/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

 MP:0011139 increased lung endothelial cell proliferation "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Acetm9Keb/Acetm9Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Fxnem2Lutzy/Fxnem2.1Lutzy,Tg(Ckmm-cre)5Khn/?
Genetic Background: B6.Cg-Fxnem2Lutzy Fxnem2.1Lutzy Tg(Ckmm-cre)5Khn/J

 MP:0011661 persistent truncus arteriosus type i "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is characterized by origin of a single pulmonary trunk from the left lateral aspect of the common trunk, with branching of the left and right pulmonary arteries from the pulmonary trunk" [http://emedicine.medscape.com]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0011664 persistent truncus arteriosus type iv "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is a form of the lesion with neither pulmonary arterial branch arises from the common trunk, and is more commonly recognized to be a form of pulmonary atresia with ventricular septal defect rather than truncus arteriosus" [http://emedicine.medscape.com]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0012250 absent heart valves "failure to form all of the membranous folds of the heart that prevent reflux of fluid" [MGI:anna]
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Allelic Composition: Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd/Polr2aTn(pb-CAG-GCaMP5g,-tdTomato)Tvrd
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021706 Q80U44 / Zfyve16 / zinc finger, FYVE domain containing 16 / Q7Z3T8* / zinc finger FYVE-type containing 16*  / complex / reaction
 ENSMUSG00000027358 Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*  / reaction / complex
 ENSMUSG00000052430 Bmpr1b / P36898 / Mus musculus bone morphotic protein receptor, type 1B (Bmpr1b), transcript variant 6, mRNA. / O00238* / bone morphogenetic protein receptor type 1B*  / reaction / complex
 ENSMUSG00000021796 Bmpr1a / P36895 / Bone morphotic protein receptor type-1A / P36894* / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSMUSG00000018363 A2A5Z6 / Smurf2 / E3 ubiquitin-protein ligase SMURF2 / Q9HAU4* / SMAD specific E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000067336 Bmpr2 / O35607 / Bone morphotic protein receptor type-2 / Q13873* / bone morphogenetic protein receptor type 2*  / complex
 ENSMUSG00000025880 Smad7 / O35253 / SMAD family member 7 / O15105*  / complex / reaction
 ENSMUSG00000031681 Smad1 / P70340 / SMAD family member 1 / Q15797*  / complex / reaction
 ENSMUSG00000027796 Smad9 / Q9JIW5 / Mothers against decapentaplegic homolog 9 / O15198* / SMAD family member 9*  / complex / reaction
 ENSMUSG00000038780 Q9CUN6 / Smurf1 / E3 ubiquitin-protein ligase SMURF1 / Q9HCE7* / SMAD specific E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000021540 Smad5 / P97454 / Mothers against decapentaplegic homolog 5 / Q99717* / SMAD family member 5*  / complex / reaction
 ENSMUSG00000036867 Smad6 / O35182 / Mothers against decapentaplegic homolog 6 / O43541* / SMAD family member 6*  / reaction / complex
 ENSMUSG00000052155 Acvr2a / P27038 / Activin receptor type-2A / P27037* / activin A receptor type 2A*  / complex
 ENSMUSG00000061393 Acvr2b / P27040 / Activin receptor type-2B / Q13705* / activin A receptor type 2B*  / complex






 

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