ENSGALG00000008459


Gallus gallus

Features
Gene ID: ENSGALG00000008459
  
Biological name :BMPR2
  
Synonyms : BMPR2 / bone morphogenetic protein receptor type 2
  
Possible biological names infered from orthology : Bone morphotic protein receptor type-2 / O35607 / Q13873
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 11874180
Gene end: 11969327
  
Corresponding Affymetrix probe sets: Gga.105.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013771
Ensembl peptide - ENSGALP00000058326
NCBI entrez gene - 374147     See in Manteia.
RefSeq - XM_015289366
RefSeq - NM_001001465
RefSeq Peptide - NP_001001465
swissprot - O42124
swissprot - F6RIN4
Ensembl - ENSGALG00000008459
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmpr2aENSDARG00000011941Danio rerio
 bmpr2bENSDARG00000020057Danio rerio
 BMPR2ENSG00000204217Homo sapiens
 Bmpr2ENSMUSG00000067336Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244417
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615817
ENSGALG0000001205514
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221614
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144214
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125714
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730113
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563513
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959913
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200313
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015770  Bone morphogenetic protein receptor type-2
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001946 lymphangiogenesis IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002063 chondrocyte development ISS
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003183 mitral valve morphogenesis IEA
 biological_processGO:0003186 tricuspid valve morphogenesis IEA
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0014916 regulation of lung blood pressure IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030166 proteoglycan biosynthetic process IMP
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IEA
 biological_processGO:0060173 limb development IEA
 biological_processGO:0060350 endochondral bone morphogenesis IMP
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060836 lymphatic endothelial cell differentiation IEA
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060841 venous blood vessel development IEA
 biological_processGO:0061036 positive regulation of cartilage development IMP
 biological_processGO:0061298 retina vasculature development in camera-type eye IEA
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:1902731 negative regulation of chondrocyte proliferation ISS
 biological_processGO:1905314 semi-lunar valve development IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0036122 BMP binding IEA
 molecular_functionGO:0098821 BMP receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / complex
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / complex
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / complex
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / complex / reaction
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / reaction / complex
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / reaction / complex
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / reaction / complex






 

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