ENSGALG00000029301


Gallus gallus

Features
Gene ID: ENSGALG00000029301
  
Biological name :BMP2
  
Synonyms : BMP2 / bone morphogenetic protein 2 precursor
  
Possible biological names infered from orthology : bone morphogenetic protein 2 / Bone morphotic protein 2 / P12643 / P21274
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 15110369
Gene end: 15113622
  
Corresponding Affymetrix probe sets: Gga.19960.1.S1_at (Chicken Array)   Gga.3950.1.S1_at (Chicken Array)   Gga.3950.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047229
NCBI entrez gene - 378779     See in Manteia.
RefSeq - NM_204358
RefSeq - XM_015283435
RefSeq Peptide - NP_989689
swissprot - A0A1D5P3H4
Ensembl - ENSGALG00000029301
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp2aENSDARG00000013409Danio rerio
 bmp2bENSDARG00000041430Danio rerio
 BMP2ENSG00000125845Homo sapiens
 Bmp2ENSMUSG00000027358Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSGALG0000001242963
BMP5 / bone morphogenetic protein 5 / P22003* / P49003* / Bone morphotic protein 5 *ENSGALG0000001629333
BMP8B* / BMP8A* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8A * / Bone morphotic protein 8B * / bone morphogenetic protein 8a* / bone morphogenetic protein 8b*ENSGALG0000003898433
BMP7 / bone morphogenetic protein 7 / P18075* / P23359* / Bone morphotic protein 7 *ENSGALG0000000766832
BMP10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSGALG0000000012031
GDF5 / growth/differentiation factor 5 precursor / P43026* / P43027* / growth differentiation factor 5*ENSGALG0000003835529
ADMP / anti-dorsalizing morphogenetic protein precursor ENSGALG0000003740829
GDF2 / P34822 / Dorsalin-1 / Q9WV56* / Q9UK05* / growth differentiation factor 2*ENSGALG0000000598128
BMP6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSGALG0000001278727
ENSGALG0000000623927
GDF6 / growth differentiation factor 6 / P43028* / Q6KF10*ENSGALG0000003590125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0003130 BMP signaling pathway involved in heart induction IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003308 negative regulation of Wnt signaling pathway involved in heart development IEA
 biological_processGO:0006029 proteoglycan metabolic process IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0010922 positive regulation of phosphatase activity IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021978 telencephalon regionalization IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032348 negative regulation of aldosterone biosynthetic process IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0035051 cardiocyte differentiation IEA
 biological_processGO:0035054 embryonic heart tube anterior/posterior pattern specification IEA
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042482 positive regulation of odontogenesis IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048762 mesenchymal cell differentiation IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0051042 negative regulation of calcium-independent cell-cell adhesion IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IEA
 biological_processGO:0060039 pericardium development IEA
 biological_processGO:0060128 corticotropin hormone secreting cell differentiation IEA
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060485 mesenchyme development IEA
 biological_processGO:0060804 positive regulation of Wnt signaling pathway by BMP signaling pathway IEA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:2000065 negative regulation of cortisol biosynthetic process IEA
 biological_processGO:2000726 negative regulation of cardiac muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070724 BMP receptor complex IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0019211 phosphatase activator activity IEA
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070700 BMP receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / reaction / complex
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / complex / reaction
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / complex / reaction
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / reaction / complex
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / reaction / complex
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / reaction / complex
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex / reaction
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex






 

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