ENSGALG00000012444


Gallus gallus

Features
Gene ID: ENSGALG00000012444
  
Biological name :ACVR2A
  
Synonyms : Activin receptor type-2A / ACVR2A / Q90669
  
Possible biological names infered from orthology : activin A receptor type 2A / P27037 / P27038
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 34687035
Gene end: 34741921
  
Corresponding Affymetrix probe sets: Gga.2852.1.S1_at (Chicken Array)   Gga.2852.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037012
Ensembl peptide - ENSGALP00000060738
Ensembl peptide - ENSGALP00000060292
NCBI entrez gene - 396324     See in Manteia.
RefSeq - NM_205367
RefSeq - XM_015289792
RefSeq Peptide - NP_990698
swissprot - A0A1L1RPN2
swissprot - A0A1L1RNE2
swissprot - Q90669
Ensembl - ENSGALG00000012444
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvr2aaENSDARG00000011188Danio rerio
 acvr2abENSDARG00000104700Danio rerio
 ACVR2AENSG00000121989Homo sapiens
 Acvr2aENSMUSG00000052155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615871
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845935
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144234
ENSGALG0000001205532
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200329
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125729
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221628
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959928
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317928
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730128
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009798 axis specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030510 regulation of BMP signaling pathway IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0032927 positive regulation of activin receptor signaling pathway IEA
 biological_processGO:0042713 sperm ejaculation IEA
 biological_processGO:0043084 penile erection IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048333 mesodermal cell differentiation IMP
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0060011 Sertoli cell proliferation IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034673 inhibin-betaglycan-ActRII complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017002 activin-activated receptor activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0034711 inhibin binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048185 activin binding IEA
 molecular_functionGO:0098821 BMP receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Activin
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / complex / reaction
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / complex / reaction
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / reaction / complex
 ENSGALG00000029599 ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *  / reaction / complex
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / reaction / complex
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / complex / reaction
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / complex / reaction
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / complex / reaction
 ENSGALG00000041257 ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *  / complex
 ENSGALG00000028770 INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*  / reaction / complex
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / complex / reaction
 ENSGALG00000034616 INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*  / complex / reaction






 

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