ENSGALG00000033179


Gallus gallus

Features
Gene ID: ENSGALG00000033179
  
Biological name :TGFBR1
  
Synonyms : TGFBR1 / transforming growth factor beta receptor 1
  
Possible biological names infered from orthology : P36897 / Q64729 / transforming growth factor, beta receptor I
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 56104804
Gene end: 56137792
  
Corresponding Affymetrix probe sets: Gga.143.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054311
NCBI entrez gene - 374094     See in Manteia.
RefSeq - NM_204246
RefSeq - XM_015275817
RefSeq Peptide - NP_989577
swissprot - Q06900
Ensembl - ENSGALG00000033179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfbr1aENSDARG00000017494Danio rerio
 tgfbr1bENSDARG00000042259Danio rerio
 P36897ENSG00000106799Homo sapiens
 Q64729ENSMUSG00000007613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959971
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125764
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221651
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200350
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730148
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563547
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144229
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615828
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244428
ENSGALG0000001205528
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISA
 biological_processGO:0001501 skeletal system development ISA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0001837 epithelial to mesenchymal transition ISA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002088 lens development in camera-type eye ISA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISA
 biological_processGO:0006468 protein phosphorylation ISA
 biological_processGO:0007165 signal transduction ISA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008354 germ cell migration ISA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031396 regulation of protein ubiquitination ISA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032924 activin receptor signaling pathway IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042118 endothelial cell activation IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043393 regulation of protein binding ISA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development ISA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis ISA
 biological_processGO:0048705 skeletal system morphogenesis ISA
 biological_processGO:0048762 mesenchymal cell differentiation IMP
 biological_processGO:0048844 artery morphogenesis ISA
 biological_processGO:0048870 cell motility ISA
 biological_processGO:0051272 positive regulation of cellular component movement ISA
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISA
 biological_processGO:0060017 parathyroid gland development ISA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060037 pharyngeal system development ISA
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IMP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISA
 biological_processGO:0060412 ventricular septum morphogenesis IEA
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis ISS
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0070723 response to cholesterol ISA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus ISA
 biological_processGO:1905075 positive regulation of occluding junction disassembly IEA
 biological_processGO:1905223 epicardium morphogenesis ISS
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISA
 cellular_componentGO:0005623 cell IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043235 receptor complex ISA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity ISA
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I ISA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IMP
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005524 ATP binding ISA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding ISA
 molecular_functionGO:0046332 SMAD binding ISA
 molecular_functionGO:0050431 transforming growth factor beta binding ISA
 molecular_functionGO:0070411 I-SMAD binding ISA


Pathways (from Reactome)
Pathway description
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / complex
 ENSGALG00000010613 ZFYVE9 / zinc finger FYVE-type containing 9 / O95405* / zinc finger, FYVE domain containing 9*  / reaction / complex
 ENSGALG00000013092 STRAP / Q5ZL33 / Serine-threonine kinase receptor-associated protein / Q9Y3F4* / Q9Z1Z2*  / complex
 ENSGALG00000011442 Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction / complex
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000040993 BAMBI / BMP and activin membrane bound inhibitor / Q13145* / Q9D0L6* / BMP and activin membrane-bound inhibitor homolog *  / reaction / complex
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / reaction / complex
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSGALG00000027151 FKBP1C / FKBP1A* / P26883* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A* / Peptidyl-prolyl cis-trans isomerase FKBP1A *  / reaction / complex






 

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