Manteia

ENSMUSG00000030704

Mus musculus

Features

Gene ID:	ENSMUSG00000030704

Biological name :	Rab6a

Synonyms :	P35279 / Rab6a / RAB6A, member RAS oncogene family

Possible biological names infered from orthology :	P20340 / Q9H0N0 / RAB6C / RAB6C, member RAS oncogene family / RAB6D / RAB6D, member RAS oncogene family

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	E2
Gene start:	100607410
Gene end:	100641268

Corresponding Affymetrix probe sets:	10555414 (MoGene1.0st) 1447776_x_at (Mouse Genome 430 2.0 Array) 1448304_a_at (Mouse Genome 430 2.0 Array) 1448305_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000032946 Ensembl peptide - ENSMUSP00000095852 Ensembl peptide - ENSMUSP00000102663 NCBI entrez gene - 19346 See in Manteia. MGI - MGI:894313 RefSeq - NM_001163663 RefSeq - NM_024287 RefSeq Peptide - NP_001157135 RefSeq Peptide - NP_077249 swissprot - Q3U4W5 swissprot - P35279 swissprot - Q0PD54 swissprot - D3YV69 Ensembl - ENSMUSG00000030704

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rab6a	ENSDARG00000103714	Danio rerio
RAB6A	ENSGALG00000017320	Gallus gallus
RAB6A	ENSG00000175582	Homo sapiens
RAB6C	ENSG00000222014	Homo sapiens
RAB6D	ENSG00000233087	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Rab6b / P61294 / RAB6B, member RAS oncogene family / Q9NRW1*	ENSMUSG00000032549	91
Rab36 / Q8CAM5 / Mus musculus RAB36, member RAS onco family (Rab36), transcript variant 1, mRNA. / O95755* / RAB36, member RAS oncogene family*	ENSMUSG00000020175	37
Rab34 / RAB34, member RAS oncogene family / P0DI83* / Q9BZG1*	ENSMUSG00000002059	35

Protein motifs (from Interpro)

Interpro ID	Name
IPR001806	Small GTPase superfamily
IPR005225	Small GTP-binding protein domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006886	intracellular protein transport	TAS
biological_process	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	ISS
biological_process	GO:0006891	intra-Golgi vesicle-mediated transport	IBA
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
biological_process	GO:0018125	peptidyl-cysteine methylation	ISO
biological_process	GO:0019882	antigen processing and presentation	ISO
biological_process	GO:0034067	protein localization to Golgi apparatus	ISS
biological_process	GO:0034498	early endosome to Golgi transport	ISO
biological_process	GO:0042147	retrograde transport, endosome to Golgi	IBA
cellular_component	GO:0000139	Golgi membrane	ISO
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005802	trans-Golgi network	ISO
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0016020	membrane	ISO
cellular_component	GO:0031410	cytoplasmic vesicle	ISO
cellular_component	GO:0070381	endosome to plasma membrane transport vesicle	ISO
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005525	GTP binding	ISO
molecular_function	GO:0019904	protein domain specific binding	ISO
molecular_function	GO:0031489	myosin V binding	ISO

Pathways (from Reactome)

Pathway description

Neutrophil degranulation

COPI-independent Golgi-to-ER retrograde traffic

Retrograde transport at the Trans-Golgi-Network

TBC/RABGAPs

RAB geranylgeranylation

RAB GEFs exchange GTP for GDP on RABs

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003886	abnormal embryonic epiblast morphology	"anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ace2^tm1Pngr/Y,Pik3cg^tm1Pngr/Pik3cg^tm1Pngr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Ace2^tm1Pngr/Y,Pik3cg^tm1Pngr/Pik3cg^tm1Pngr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011106	partial embryonic lethality before somite formation	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Ace2^tm1Pngr/Y,Pik3cg^tm1Pngr/Pik3cg^tm1Pngr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0014134	abnormal embryo morphology	"any structural anomaly of an embryo " [MGI:csmith]	Show Allelic Composition: Ace2^tm1Pngr/Y,Pik3cg^tm1Pngr/Pik3cg^tm1Pngr Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000420	Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*	/ reaction / complex
ENSMUSG00000020483	Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*	/ reaction / complex
ENSMUSG00000020745	P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*	/ reaction
ENSMUSG00000015291	Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*	/ complex
ENSMUSG00000018707	Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*	/ complex / reaction
ENSMUSG00000015733	Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*	/ complex / reaction
ENSMUSG00000025531	Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*	/ complex
ENSMUSG00000021076	Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*	/ reaction / complex
ENSMUSG00000025410	Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*	/ reaction / complex
ENSMUSG00000024603	Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*	/ complex / reaction
ENSMUSG00000028468	Rgp1 / Q8BHT7 / RAB6A-GEF complex partner protein 2 / Q92546* / RGP1 homolog, RAB6A GEF complex partner 1*	/ complex / reaction
ENSMUSG00000028745	Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*	/ reaction / complex
ENSMUSG00000041791	Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*	/ complex / reaction
ENSMUSG00000031516	Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*	/ reaction / complex
ENSMUSG00000030868	Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*	/ complex / reaction
ENSMUSG00000035770	Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*	/ reaction / complex
ENSMUSG00000025228	Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*	/ complex / reaction
ENSMUSG00000028447	Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*	/ reaction / complex
ENSMUSG00000003452	Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*	/ reaction / complex
ENSMUSG00000038658	Ric1 / Q69ZJ7 / RAB6A-GEF complex partner protein 1 / Q4ADV7* / RIC1 homolog, RAB6A GEF complex partner 1*	/ complex / reaction
ENSMUSG00000035437	A2AWA9 / Rabgap1 / RAB GTPase activating protein 1 / Q9Y3P9*	/ reaction / complex
ENSMUSG00000032435	Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*	/ complex / reaction
ENSMUSG00000021218	Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*	/ complex
ENSMUSG00000027012	O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*	/ reaction / complex
ENSMUSG00000031865	Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*	/ complex / reaction
ENSMUSG00000064063	BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*	/ complex / reaction
ENSMUSG00000078185	Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*	/ complex
ENSMUSG00000029757	O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*	/ complex / reaction
ENSMUSG00000092329	Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr