ENSMUSG00000003452


Mus musculus

Features
Gene ID: ENSMUSG00000003452
  
Biological name :Bicd1
  
Synonyms : Bicd1 / Protein bicaudal D homolog 1 / Q8BR07
  
Possible biological names infered from orthology : BICD cargo adaptor 1 / Q96G01
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G3
Gene start: 149408886
Gene end: 149563329
  
Corresponding Affymetrix probe sets: 10542896 (MoGene1.0st)   1427530_at (Mouse Genome 430 2.0 Array)   1437548_at (Mouse Genome 430 2.0 Array)   1438701_at (Mouse Genome 430 2.0 Array)   1439431_x_at (Mouse Genome 430 2.0 Array)   1451684_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084039
Ensembl peptide - ENSMUSP00000133727
Ensembl peptide - ENSMUSP00000133986
Ensembl peptide - ENSMUSP00000003544
Ensembl peptide - ENSMUSP00000107138
NCBI entrez gene - 12121     See in Manteia.
MGI - MGI:1101760
RefSeq - XM_006507024
RefSeq - XM_006507016
RefSeq - XM_006507017
RefSeq - XM_006507018
RefSeq - XM_006507019
RefSeq - XM_006507020
RefSeq - XM_006507023
RefSeq - NM_001112796
RefSeq - NM_009753
RefSeq - XM_006507014
RefSeq - XM_006507015
RefSeq Peptide - NP_001106267
RefSeq Peptide - NP_033883
swissprot - G3UY88
swissprot - G3UXK5
swissprot - Q8BR07
swissprot - B2KG46
Ensembl - ENSMUSG00000003452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bicd1aENSDARG00000079496Danio rerio
 CABZ01085700.1ENSDARG00000098551Danio rerio
 ENSGALG00000032522Gallus gallus
 BICD1ENSG00000151746Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bicd2 / Q921C5 / Protein bicaudal D homolog 2 / Q8TD16* / BICD cargo adaptor 2*ENSMUSG0000003793362


Protein motifs (from Interpro)
Interpro ID Name
 IPR018477  Bicaudal-D protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016032 viral process ISO
 biological_processGO:0033365 protein localization to organelle ISO
 biological_processGO:0034063 stress granule assembly IMP
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis ISO
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISO
 biological_processGO:0072385 minus-end-directed organelle transport along microtubule ISO
 biological_processGO:0072393 microtubule anchoring at microtubule organizing center IMP
 biological_processGO:1900275 negative regulation of phospholipase C activity IDA
 biological_processGO:1900276 regulation of proteinase activated receptor activity IDA
 biological_processGO:1900737 negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:1904781 positive regulation of protein localization to centrosome ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005881 cytoplasmic microtubule ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0072517 host cell viral assembly compartment ISO
 molecular_functionGO:0008093 cytoskeletal adaptor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031871 proteinase activated receptor binding IPI
 molecular_functionGO:0034452 dynactin binding ISO
 molecular_functionGO:0045505 dynein intermediate chain binding ISO
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000420 Galnt1 / O08912 / Polypeptide N-acetylgalactosaminyltransferase 1 Polypeptide N-acetylgalactosaminyltransferase 1 soluble form / Q10472* / polypeptide N-acetylgalactosaminyltransferase 1*  / reaction / complex
 ENSMUSG00000003452 Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*  / complex
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / complex / reaction
 ENSMUSG00000020745 P63005 / Pafah1b1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 / P43034* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*  / reaction
 ENSMUSG00000018707 Q9JHU4 / Dync1h1 / Cytoplasmic dynein 1 heavy chain 1 / Q14204* / dynein cytoplasmic 1 heavy chain 1*  / reaction / complex
 ENSMUSG00000015733 Capza2 / P47754 / F-actin-capping protein subunit alpha-2 / P47755* / capping actin protein of muscle Z-line alpha subunit 2*  / complex / reaction
 ENSMUSG00000021076 Actr10 / Q9QZB7 / Actin-related protein 10 / Q9NZ32* / actin related protein 10 homolog*  / reaction / complex
 ENSMUSG00000025410 Dctn2 / Q99KJ8 / Dynactin subunit 2 / Q13561*  / reaction / complex
 ENSMUSG00000024603 Dctn4 / Q8CBY8 / Mus musculus dynactin 4 (Dctn4), transcript variant 2, mRNA. / Q9UJW0* / dynactin subunit 4*  / reaction / complex
 ENSMUSG00000028745 Capzb / P47757 / F-actin-capping protein subunit beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex / reaction
 ENSMUSG00000041791 Capza3 / P70190 / F-actin-capping protein subunit alpha-3 / Q96KX2* / capping actin protein of muscle Z-line alpha subunit 3*  / complex / reaction
 ENSMUSG00000031516 Dctn6 / Q9WUB4 / Dynactin subunit 6 / O00399*  / reaction / complex
 ENSMUSG00000030868 Dctn5 / Q9QZB9 / Dynactin subunit 5 / Q9BTE1*  / complex / reaction
 ENSMUSG00000035770 Q6PDL0 / Dync1li2 / Cytoplasmic dynein 1 light intermediate chain 2 / O43237* / dynein cytoplasmic 1 light intermediate chain 2*  / complex / reaction
 ENSMUSG00000025228 Actr1a / P61164 / Alpha-centractin / P61163* / ARP1 actin related protein 1 homolog A*  / reaction / complex
 ENSMUSG00000028447 Dctn3 / Q9Z0Y1 / Dynactin subunit 3 / O75935*  / complex / reaction
 ENSMUSG00000030704 Rab6a / P35279 / RAB6A, member RAS oncogene family / RAB6C* / RAB6D* / Q9H0N0* / P20340* / RAB6C, member RAS oncogene family* / RAB6D, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000032435 Q8R1Q8 / Dync1li1 / Cytoplasmic dynein 1 light intermediate chain 1 / Q9Y6G9* / dynein cytoplasmic 1 light intermediate chain 1*  / reaction / complex
 ENSMUSG00000027012 O88487 / Dync1i2 / Mus musculus dynein cytoplasmic 1 intermediate chain 2 (Dync1i2), transcript variant 9, mRNA. / Q13409* / dynein cytoplasmic 1 intermediate chain 2*  / complex / reaction
 ENSMUSG00000031865 Dctn1 / O08788 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / Q14203* / dynactin subunit 1*  / reaction / complex
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction / complex
 ENSMUSG00000029757 O88485 / Dync1i1 / Cytoplasmic dynein 1 intermediate chain 1 / O14576* / dynein cytoplasmic 1 intermediate chain 1*  / complex / reaction
 ENSMUSG00000092329 Q6PB93 / Gm20388 / predicted gene 20388 / GALNT2* / Q10471* / polypeptide N-acetylgalactosaminyltransferase 2*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr