ENSMUSG00000037933


Mus musculus

Features
Gene ID: ENSMUSG00000037933
  
Biological name :Bicd2
  
Synonyms : Bicd2 / Protein bicaudal D homolog 2 / Q921C5
  
Possible biological names infered from orthology : BICD cargo adaptor 2 / Q8TD16
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A5
Gene start: 49341585
Gene end: 49387026
  
Corresponding Affymetrix probe sets: 10405001 (MoGene1.0st)   1422745_at (Mouse Genome 430 2.0 Array)   1422746_s_at (Mouse Genome 430 2.0 Array)   1437491_at (Mouse Genome 430 2.0 Array)   1437875_at (Mouse Genome 430 2.0 Array)   1450732_a_at (Mouse Genome 430 2.0 Array)   1450733_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105712
Ensembl peptide - ENSMUSP00000152090
Ensembl peptide - ENSMUSP00000039394
Ensembl peptide - ENSMUSP00000105711
NCBI entrez gene - 76895     See in Manteia.
MGI - MGI:1924145
RefSeq - NM_001039179
RefSeq - NM_001039180
RefSeq - NM_029791
RefSeq Peptide - NP_001034269
RefSeq Peptide - NP_084067
RefSeq Peptide - NP_001034268
swissprot - Q921C5
swissprot - A0A1Y7VIQ5
swissprot - D3Z390
Ensembl - ENSMUSG00000037933
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bicd2ENSDARG00000075571Danio rerio
 CU914536.1ENSDARG00000098215Danio rerio
 BICD2ENSGALG00000005249Gallus gallus
 BICD2ENSG00000185963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bicd1 / Q8BR07 / Protein bicaudal D homolog 1 / Q96G01* / BICD cargo adaptor 1*ENSMUSG0000000345261


Protein motifs (from Interpro)
Interpro ID Name
 IPR018477  Bicaudal-D protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP
 biological_processGO:0007018 microtubule-based movement IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051642 centrosome localization ISS
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISO
 biological_processGO:0072385 minus-end-directed organelle transport along microtubule IMP
 biological_processGO:0072393 microtubule anchoring at microtubule organizing center IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope ISS
 cellular_componentGO:0005642 annulate lamellae ISS
 cellular_componentGO:0005643 nuclear pore ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008093 cytoskeletal adaptor activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0034452 dynactin binding IDA
 molecular_functionGO:0051959 dynein light intermediate chain binding IPI
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000888 absent cerebellar granule layer "missing innermost cortical layer of the cerebellum" [J:46854]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009512 abnormal cerebellar Golgi cell morphology "any structural anomaly of the population of large inhibitory GABAergic interneurons found in the cerebellar internal granule layer which act by altering the mossy fibre - granule cell synapse; the main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus, which is composed of the mossy fibre terminal, granule cell dendrites, and golgi terminal and is enclosed by a glial coat" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(Nes-cre)1Atp/0
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009978 abnormal cerebellum white matter morphology 
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010540 long stride length "increased average distance between steps" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012004 abnormal septum pellucidum morphology "any structural anomaly of the thin, triangular, vertical membrane separating the anterior horns of the left and righ of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala" [MGI:csmith, MPD:Molly]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012508 forebrain atrophy "acquired diminution of the size of the forebrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020141 decreased brain external capsule size "smaller than the normal physical proportions of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Bicd2tm1Hgrd/Bicd2tm1Hgrd,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0030003 hippocampus atrophy "acquired diminution of the size of the hippocampus associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [MGI:anna]
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Allelic Composition: Srrm4tm1b(EUCOMM)Wtsi/Srrm4+
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037933 Bicd2 / Q921C5 / Protein bicaudal D homolog 2 / Q8TD16* / BICD cargo adaptor 2*  / complex






 

1 s.

 
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