ENSMUSG00000020740


Mus musculus

Features
Gene ID: ENSMUSG00000020740
  
Biological name :Gga3
  
Synonyms : ADP-ribosylation factor-binding protein GGA3 / Gga3 / Q8BMI3
  
Possible biological names infered from orthology : golgi associated, gamma adaptin ear containing, ARF binding protein 3 / Q9NZ52
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115584255
Gene end: 115604051
  
Corresponding Affymetrix probe sets: 10392953 (MoGene1.0st)   1438008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138597
Ensembl peptide - ENSMUSP00000019135
Ensembl peptide - ENSMUSP00000102117
Ensembl peptide - ENSMUSP00000118024
NCBI entrez gene - 260302     See in Manteia.
MGI - MGI:2384159
RefSeq - XM_011249032
RefSeq - NM_001252067
RefSeq - NM_173048
RefSeq - XM_006533365
RefSeq - XM_011249031
RefSeq Peptide - NP_766636
RefSeq Peptide - NP_001238996
swissprot - Q8BMI3
swissprot - A2A9W7
swissprot - S4R2D2
swissprot - A2A9W5
Ensembl - ENSMUSG00000020740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gga3ENSDARG00000103667Danio rerio
 GGA3 (1 of many)ENSDARG00000098871Danio rerio
 GGA3ENSGALG00000007992Gallus gallus
 GGA3ENSG00000125447Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gga1 / Q8R0H9 / ADP-ribosylation factor-binding protein GGA1 / Q9UJY5* / golgi associated, gamma adaptin ear containing, ARF binding protein 1*ENSMUSG0000003312849
Gga2 / Q6P5E6 / ADP-ribosylation factor-binding protein GGA2 / Q9UJY4* / golgi associated, gamma adaptin ear containing, ARF binding protein 2*ENSMUSG0000003087238
Q5SRX1 / Tom1l2 / TOM1-like protein 2 / Q6ZVM7* / target of myb1 like 2 membrane trafficking protein*ENSMUSG0000000053816
Tom1 / O88746 / target of myb1 trafficking protein / O60784* / target of myb1 membrane trafficking protein*ENSMUSG0000004287015
Q923U0 / Tom1l1 / target of myb1-like 1 (chicken) / O75674* / target of myb1 like 1 membrane trafficking protein*ENSMUSG0000002054112


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR027422  ADP-ribosylation factor-binding protein GGA3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA


Pathways (from Reactome)
Pathway description
MET receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1+,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000044147 Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000006134 Crkl / P47941 / Crk-like protein / P46109* / CRK like proto-oncogene, adaptor protein*  / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex






 

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