ENSG00000125447


Homo sapiens

Features
Gene ID: ENSG00000125447
  
Biological name :GGA3
  
Synonyms : GGA3 / golgi associated, gamma adaptin ear containing, ARF binding protein 3 / Q9NZ52
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 75236599
Gene end: 75262363
  
Corresponding Affymetrix probe sets: 209411_s_at (Human Genome U133 Plus 2.0 Array)   211815_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479464
Ensembl peptide - ENSP00000464574
Ensembl peptide - ENSP00000481953
Ensembl peptide - ENSP00000484733
Ensembl peptide - ENSP00000438085
Ensembl peptide - ENSP00000446421
Ensembl peptide - ENSP00000461963
Ensembl peptide - ENSP00000462081
Ensembl peptide - ENSP00000462279
Ensembl peptide - ENSP00000462473
Ensembl peptide - ENSP00000462629
Ensembl peptide - ENSP00000463115
Ensembl peptide - ENSP00000463288
Ensembl peptide - ENSP00000464268
Ensembl peptide - ENSP00000464318
Ensembl peptide - ENSP00000464365
NCBI entrez gene - 23163     See in Manteia.
OMIM - 606006
RefSeq - XM_017024392
RefSeq - NM_001172703
RefSeq - NM_001172704
RefSeq - NM_001291641
RefSeq - NM_001291642
RefSeq - NM_014001
RefSeq - NM_138619
RefSeq - XM_011524563
RefSeq - XM_017024385
RefSeq - XM_017024386
RefSeq - XM_017024387
RefSeq - XM_017024388
RefSeq - XM_017024389
RefSeq - XM_017024390
RefSeq - XM_017024391
RefSeq Peptide - NP_001166174
RefSeq Peptide - NP_001166175
RefSeq Peptide - NP_001278570
RefSeq Peptide - NP_001278571
RefSeq Peptide - NP_054720
RefSeq Peptide - NP_619525
swissprot - J3KSS7
swissprot - Q9NZ52
swissprot - J3QRK7
swissprot - J3QRP3
swissprot - J3QRS8
swissprot - J3QS87
swissprot - J3KTR5
swissprot - A0A087WYN2
swissprot - B7Z1E9
swissprot - G3V1K5
swissprot - J3KS27
swissprot - J3KSG3
Ensembl - ENSG00000125447
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gga3ENSDARG00000103667Danio rerio
 GGA3 (1 of many)ENSDARG00000098871Danio rerio
 GGA3ENSGALG00000007992Gallus gallus
 Gga3ENSMUSG00000020740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1ENSG0000010008349
GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2ENSG0000010336539
Q6ZVM7 / TOM1L2 / target of myb1 like 2 membrane trafficking proteinENSG0000017566217
TOM1 / O60784 / target of myb1 membrane trafficking proteinENSG0000010028416
O75674 / TOM1L1 / target of myb1 like 1 membrane trafficking proteinENSG0000014119814


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR027422  ADP-ribosylation factor-binding protein GGA3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0055038 recycling endosome membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
MET receptor recycling
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / complex
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex
 ENSG00000165527 ARF6 / P62330 / ADP ribosylation factor 6  / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex
 ENSG00000108774 RAB5C / P51148 / RAB5C, member RAS oncogene family  / complex
 ENSG00000099942 CRKL / P46109 / CRK like proto-oncogene, adaptor protein  / complex
 ENSG00000111540 RAB5B / P61020 / RAB5B, member RAS oncogene family  / complex
 ENSG00000186318 BACE1 / P56817 / beta-secretase 1  / complex / reaction
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex






 

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