ENSG00000100083


Homo sapiens

Features
Gene ID: ENSG00000100083
  
Biological name :GGA1
  
Synonyms : GGA1 / golgi associated, gamma adaptin ear containing, ARF binding protein 1 / Q9UJY5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 37608475
Gene end: 37633564
  
Corresponding Affymetrix probe sets: 1554670_at (Human Genome U133 Plus 2.0 Array)   217560_at (Human Genome U133 Plus 2.0 Array)   218114_at (Human Genome U133 Plus 2.0 Array)   45572_s_at (Human Genome U133 Plus 2.0 Array)   50277_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385287
Ensembl peptide - ENSP00000416153
Ensembl peptide - ENSP00000414413
Ensembl peptide - ENSP00000411727
Ensembl peptide - ENSP00000411373
Ensembl peptide - ENSP00000404453
Ensembl peptide - ENSP00000403534
Ensembl peptide - ENSP00000402930
Ensembl peptide - ENSP00000400159
Ensembl peptide - ENSP00000395901
Ensembl peptide - ENSP00000390416
Ensembl peptide - ENSP00000321288
Ensembl peptide - ENSP00000341344
Ensembl peptide - ENSP00000371175
Ensembl peptide - ENSP00000384030
NCBI entrez gene - 26088     See in Manteia.
OMIM - 606004
RefSeq - XM_005261518
RefSeq - XM_005261520
RefSeq - XM_005261522
RefSeq - XM_017028762
RefSeq - XM_017028761
RefSeq - XM_017028760
RefSeq - XM_011530124
RefSeq - XM_011530123
RefSeq - NM_001001560
RefSeq - NM_001172687
RefSeq - NM_001172688
RefSeq - NM_013365
RefSeq - XM_017028765
RefSeq - XM_017028764
RefSeq - XM_011530122
RefSeq - XM_017028763
RefSeq - XM_005261517
RefSeq - XM_006724229
RefSeq Peptide - NP_001166159
RefSeq Peptide - NP_001001560
RefSeq Peptide - NP_001166158
RefSeq Peptide - NP_037497
swissprot - Q9UJY5
swissprot - B0QYS5
swissprot - B0QYR5
swissprot - B0QYR6
swissprot - B0QYR8
swissprot - B0QYR9
swissprot - B0QYS0
swissprot - B0QYS1
swissprot - B0QYS2
swissprot - B0QYS3
Ensembl - ENSG00000100083
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gga1ENSDARG00000038537Danio rerio
 GGA1ENSGALG00000039658Gallus gallus
 Gga1ENSMUSG00000033128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3ENSG0000012544755
GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2ENSG0000010336546
Q6ZVM7 / TOM1L2 / target of myb1 like 2 membrane trafficking proteinENSG0000017566217
TOM1 / O60784 / target of myb1 membrane trafficking proteinENSG0000010028417
O75674 / TOM1L1 / target of myb1 like 1 membrane trafficking proteinENSG0000014119815


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:1901998 toxin transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030306 ADP-ribosylation factor binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IMP


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / complex
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000186318 BACE1 / P56817 / beta-secretase 1  / reaction / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex
 ENSG00000108774 RAB5C / P51148 / RAB5C, member RAS oncogene family  / complex
 ENSG00000111540 RAB5B / P61020 / RAB5B, member RAS oncogene family  / complex






 

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