ENSG00000154710


Homo sapiens

Features
Gene ID: ENSG00000154710
  
Biological name :RABGEF1
  
Synonyms : Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q11.21
Gene start: 66682164
Gene end: 66811464
  
Corresponding Affymetrix probe sets: 218310_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390480
Ensembl peptide - ENSP00000491800
Ensembl peptide - ENSP00000476796
Ensembl peptide - ENSP00000421124
Ensembl peptide - ENSP00000415815
Ensembl peptide - ENSP00000415503
Ensembl peptide - ENSP00000403429
Ensembl peptide - ENSP00000284957
Ensembl peptide - ENSP00000370208
NCBI entrez gene - 27342     See in Manteia.
OMIM - 609700
RefSeq - NM_014504
RefSeq - NM_001287060
RefSeq - NM_001287061
RefSeq - NM_001287062
RefSeq Peptide - NP_001273989
RefSeq Peptide - NP_001273990
RefSeq Peptide - NP_001273991
RefSeq Peptide - NP_055319
swissprot - V9GYI8
swissprot - C9JDA2
swissprot - A0A1W2PPY0
swissprot - A0A0A0MSJ3
swissprot - A0A024RDL6
swissprot - Q3HKR1
swissprot - Q9UJ41
swissprot - E9PFK9
Ensembl - ENSG00000154710
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabgef1ENSDARG00000014430Danio rerio
 rabgef1lENSDARG00000015968Danio rerio
 ENSGALG00000021611Gallus gallus
 Q9JM13ENSMUSG00000025340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAPVD1 / Q14C86 / GTPase activating protein and VPS9 domains 1ENSG0000016521920
AC027644.4ENSG0000028446113


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003123  VPS9 domain
 IPR037191  VPS9 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006612 protein targeting to membrane IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103365 GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2  / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / complex
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000100083 GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1  / complex
 ENSG00000108774 RAB5C / P51148 / RAB5C, member RAS oncogene family  / complex
 ENSG00000111540 RAB5B / P61020 / RAB5B, member RAS oncogene family  / complex
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex






 

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