ENSG00000111540


Homo sapiens

Features
Gene ID: ENSG00000111540
  
Biological name :RAB5B
  
Synonyms : P61020 / RAB5B / RAB5B, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.2
Gene start: 55973913
Gene end: 55996683
  
Corresponding Affymetrix probe sets: 201276_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450285
Ensembl peptide - ENSP00000450168
Ensembl peptide - ENSP00000487368
Ensembl peptide - ENSP00000353444
Ensembl peptide - ENSP00000391319
Ensembl peptide - ENSP00000447895
Ensembl peptide - ENSP00000449554
Ensembl peptide - ENSP00000449762
NCBI entrez gene - 5869     See in Manteia.
OMIM - 179514
RefSeq - XM_005269052
RefSeq - NM_001252036
RefSeq - NM_001252037
RefSeq - NM_002868
RefSeq - XM_005269051
RefSeq Peptide - NP_002859
RefSeq Peptide - NP_001238965
RefSeq Peptide - NP_001238966
swissprot - F8VVZ0
swissprot - F8VWZ7
swissprot - F8VPW9
swissprot - F8VUA5
swissprot - P61020
swissprot - A0A024RB09
Ensembl - ENSG00000111540
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB5BENSGALG00000042482Gallus gallus
 Rab5bENSMUSG00000000711Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB5C / P51148 / RAB5C, member RAS oncogene familyENSG0000010877485
RAB5A / P20339 / RAB5A, member RAS oncogene familyENSG0000014456682
AC099811.2ENSG0000026726164
Q9UL26 / RAB22A / RAB22A, member RAS oncogene familyENSG0000012420944
RAB31 / Q13636 / RAB31, member RAS oncogene familyENSG0000016846143
RAB17 / Q9H0T7 / RAB17, member RAS oncogene familyENSG0000012483940
RAB21 / Q9UL25 / RAB21, member RAS oncogene familyENSG0000008037138
RAB20 / Q9NX57 / RAB20, member RAS oncogene familyENSG0000013983231
Q9NZQ0 / DNAJC27 / DnaJ heat shock protein family (Hsp40) member C27ENSG0000011513726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0030100 regulation of endocytosis IBA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048227 plasma membrane to endosome transport IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030139 endocytic vesicle IBA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0030742 GTP-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
TBC/RABGAPs
Clathrin-mediated endocytosis
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000100083 GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1  / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex
 ENSG00000103365 GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2  / complex






 

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