ENSG00000168461


Homo sapiens

Features
Gene ID: ENSG00000168461
  
Biological name :RAB31
  
Synonyms : Q13636 / RAB31 / RAB31, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.22
Gene start: 9708165
Gene end: 9862551
  
Corresponding Affymetrix probe sets: 217762_s_at (Human Genome U133 Plus 2.0 Array)   217763_s_at (Human Genome U133 Plus 2.0 Array)   217764_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461945
Ensembl peptide - ENSP00000462164
Ensembl peptide - ENSP00000462561
Ensembl peptide - ENSP00000464046
NCBI entrez gene - 11031     See in Manteia.
OMIM - 605694
RefSeq - XM_017025529
RefSeq - NM_006868
RefSeq - XM_017025528
RefSeq Peptide - NP_006859
swissprot - J3KRU3
swissprot - Q13636
swissprot - J3KSM8
swissprot - J3QR51
Ensembl - ENSG00000168461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018490.1ENSDARG00000115832Danio rerio
 RAB31ENSGALG00000022874Gallus gallus
 Rab31ENSMUSG00000056515Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UL26 / RAB22A / RAB22A, member RAS oncogene familyENSG0000012420971
RAB5A / P20339 / RAB5A, member RAS oncogene familyENSG0000014456647
RAB5C / P51148 / RAB5C, member RAS oncogene familyENSG0000010877447
RAB5B / P61020 / RAB5B, member RAS oncogene familyENSG0000011154047
RAB21 / Q9UL25 / RAB21, member RAS oncogene familyENSG0000008037146
RAB17 / Q9H0T7 / RAB17, member RAS oncogene familyENSG0000012483940
AC099811.2ENSG0000026726139
RAB20 / Q9NX57 / RAB20, member RAS oncogene familyENSG0000013983231
Q9NZQ0 / DNAJC27 / DnaJ heat shock protein family (Hsp40) member C27ENSG0000011513729


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0043001 Golgi to plasma membrane protein transport IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045055 regulated exocytosis IMP
 biological_processGO:0090382 phagosome maturation IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 cellular_componentGO:0032588 trans-Golgi network membrane IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100599 RIN3 / Q8TB24 / Ras and Rab interactor 3  / reaction
 ENSG00000165219 GAPVD1 / Q14C86 / GTPase activating protein and VPS9 domains 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex






 

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