ENSG00000274611


Homo sapiens

Features
Gene ID: ENSG00000274611
  
Biological name :TBC1D3
  
Synonyms : Q8IZP1 / TBC1D3 / TBC1 domain family member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 38181659
Gene end: 38192541
  
Corresponding Affymetrix probe sets: 209403_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478683
NCBI entrez gene - 729873     See in Manteia.
OMIM - 607741
RefSeq - NM_001123391
RefSeq Peptide - NP_001116863
swissprot - Q8IZP1
Ensembl - ENSG00000274611
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-288d18.1ENSDARG00000011088Danio rerio
 si:dkeyp-19e1.3ENSDARG00000051836Danio rerio
 ENSGALG00000039221Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TBC1D3K / A0A087X1G2 / TBC1 domain family member 3KENSG00000273513100
Q6IPX1 / TBC1D3C / TBC1 domain family member 3CENSG00000278299100
TBC1D3E / A0A087X179 / TBC1 domain family member 3EENSG00000278599100
TBC1D3D / A0A087WVF3 / TBC1 domain family member 3DENSG00000274419100
TBC1D3I / A0A087WXS9 / TBC1 domain family member 3IENSG00000274933100
P0C7X1 / TBC1D3H / TBC1 domain family member 3HENSG0000027422699
A6NDS4 / TBC1D3B / TBC1 domain family member 3BENSG0000027480899
Q6DHY5 / TBC1D3G / TBC1 domain family member 3GENSG0000026028799
B9A6J9 / TBC1D3L / TBC1 domain family member 3LENSG0000027451299
TBC1D3F / TBC1 domain family member 3FENSG0000027595490
Q92738 / USP6NL / USP6 N-terminal likeENSG0000014842933
Q86UD7 / TBC1D26 / TBC1 domain family member 26ENSG0000021494623
Q9BXI6 / TBC1D10A / TBC1 domain family member 10AENSG0000009999217
Q4KMP7 / TBC1D10B / TBC1 domain family member 10BENSG0000016922117
Q2M2D7 / TBC1D28 / TBC1 domain family member 28ENSG0000018937517
Q8IV04 / TBC1D10C / TBC1 domain family member 10CENSG0000017546315
GRTP1 / Q5TC63 / growth hormone regulated TBC protein 1ENSG0000013983512
AC004997.1ENSG0000024875111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR035969  Rab-GTPase-TBC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IBA
 biological_processGO:0031338 regulation of vesicle fusion IBA
 biological_processGO:0090630 activation of GTPase activity IBA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane TAS
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0017137 Rab GTPase binding IBA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103365 GGA2 / Q9UJY4 / golgi associated, gamma adaptin ear containing, ARF binding protein 2  / complex / reaction
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / reaction / complex
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / reaction / complex
 ENSG00000100083 GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1  / complex / reaction
 ENSG00000108774 RAB5C / P51148 / RAB5C, member RAS oncogene family  / complex / reaction
 ENSG00000111540 RAB5B / P61020 / RAB5B, member RAS oncogene family  / complex / reaction
 ENSG00000125447 GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3  / complex / reaction






 

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