ENSG00000103365


Homo sapiens

Features
Gene ID: ENSG00000103365
  
Biological name :GGA2
  
Synonyms : GGA2 / golgi associated, gamma adaptin ear containing, ARF binding protein 2 / Q9UJY4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p12.2
Gene start: 23463542
Gene end: 23521995
  
Corresponding Affymetrix probe sets: 208913_at (Human Genome U133 Plus 2.0 Array)   208914_at (Human Genome U133 Plus 2.0 Array)   208915_s_at (Human Genome U133 Plus 2.0 Array)   210658_s_at (Human Genome U133 Plus 2.0 Array)   213772_s_at (Human Genome U133 Plus 2.0 Array)   214189_s_at (Human Genome U133 Plus 2.0 Array)   214190_x_at (Human Genome U133 Plus 2.0 Array)   214233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460975
Ensembl peptide - ENSP00000459414
Ensembl peptide - ENSP00000459560
Ensembl peptide - ENSP00000311962
Ensembl peptide - ENSP00000454455
Ensembl peptide - ENSP00000454469
Ensembl peptide - ENSP00000455293
Ensembl peptide - ENSP00000455331
Ensembl peptide - ENSP00000456247
NCBI entrez gene - 23062     See in Manteia.
OMIM - 606005
RefSeq - XM_017023075
RefSeq - NM_015044
RefSeq - XM_017023074
RefSeq Peptide - NP_055859
swissprot - I3L263
swissprot - I3L2C4
swissprot - H3BMM6
swissprot - Q9UJY4
swissprot - H3BMN6
swissprot - H3BPI3
swissprot - H3BPF4
Ensembl - ENSG00000103365
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GGA2ENSGALG00000006140Gallus gallus
 Gga2ENSMUSG00000030872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GGA1 / Q9UJY5 / golgi associated, gamma adaptin ear containing, ARF binding protein 1ENSG0000010008347
GGA3 / Q9NZ52 / golgi associated, gamma adaptin ear containing, ARF binding protein 3ENSG0000012544746
Q6ZVM7 / TOM1L2 / target of myb1 like 2 membrane trafficking proteinENSG0000017566217
TOM1 / O60784 / target of myb1 membrane trafficking proteinENSG0000010028416
O75674 / TOM1L1 / target of myb1 like 1 membrane trafficking proteinENSG0000014119815


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0031901 early endosome membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030306 ADP-ribosylation factor binding IDA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154710 Q9UJ41 / RABGEF1 / RAB guanine nucleotide exchange factor 1  / complex
 ENSG00000274611 Q8IZP1 / TBC1D3 / TBC1 domain family member 3  / reaction / complex
 ENSG00000186318 BACE1 / P56817 / beta-secretase 1  / reaction / complex
 ENSG00000144566 RAB5A / P20339 / RAB5A, member RAS oncogene family  / complex
 ENSG00000029725 Q15276 / RABEP1 / rabaptin, RAB GTPase binding effector protein 1  / complex
 ENSG00000108774 RAB5C / P51148 / RAB5C, member RAS oncogene family  / complex
 ENSG00000111540 RAB5B / P61020 / RAB5B, member RAS oncogene family  / complex






 

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