ENSMUSG00000030872


Mus musculus

Features
Gene ID: ENSMUSG00000030872
  
Biological name :Gga2
  
Synonyms : ADP-ribosylation factor-binding protein GGA2 / Gga2 / Q6P5E6
  
Possible biological names infered from orthology : golgi associated, gamma adaptin ear containing, ARF binding protein 2 / Q9UJY4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 121986722
Gene end: 122021222
  
Corresponding Affymetrix probe sets: 10567626 (MoGene1.0st)   1428141_at (Mouse Genome 430 2.0 Array)   1457955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033160
Ensembl peptide - ENSMUSP00000115581
NCBI entrez gene - 74105     See in Manteia.
MGI - MGI:1921355
RefSeq - NM_028758
RefSeq Peptide - NP_083034
swissprot - Q6P5E6
Ensembl - ENSMUSG00000030872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GGA2ENSGALG00000006140Gallus gallus
 GGA2ENSG00000103365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gga1 / Q8R0H9 / ADP-ribosylation factor-binding protein GGA1 / Q9UJY5* / golgi associated, gamma adaptin ear containing, ARF binding protein 1*ENSMUSG0000003312845
Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*ENSMUSG0000002074045
Q5SRX1 / Tom1l2 / TOM1-like protein 2 / Q6ZVM7* / target of myb1 like 2 membrane trafficking protein*ENSMUSG0000000053816
Tom1 / O88746 / target of myb1 trafficking protein / O60784* / target of myb1 membrane trafficking protein*ENSMUSG0000004287015
Q923U0 / Tom1l1 / target of myb1-like 1 (chicken) / O75674* / target of myb1 like 1 membrane trafficking protein*ENSMUSG0000002054111


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030306 ADP-ribosylation factor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gga2Gt(SYA176)Byg/Gga2Gt(SYA176)Byg
Genetic Background: B6J.129P2-Gga2Gt(SYA176)Byg

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Gga2Gt(SYA176)Byg/Gga2Gt(SYA176)Byg
Genetic Background: B6J.129P2-Gga2Gt(SYA176)Byg

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gga2Gt(SYA176)Byg/Gga2Gt(SYA176)Byg
Genetic Background: B6J.129P2-Gga2Gt(SYA176)Byg

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gga2Gt(SYA176)Byg/Gga2Gt(SYA176)Byg
Genetic Background: B6J.129P2-Gga2Gt(SYA176)Byg

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1+,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gga2Gt(SYA176)Byg/Gga2Gt(SYA176)Byg
Genetic Background: B6J.129P2-Gga2Gt(SYA176)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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