ENSMUSG00000033128


Mus musculus

Features
Gene ID: ENSMUSG00000033128
  
Biological name :Gga1
  
Synonyms : ADP-ribosylation factor-binding protein GGA1 / Gga1 / Q8R0H9
  
Possible biological names infered from orthology : golgi associated, gamma adaptin ear containing, ARF binding protein 1 / Q9UJY5
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 78877190
Gene end: 78894585
  
Corresponding Affymetrix probe sets: 10425120 (MoGene1.0st)   1423834_s_at (Mouse Genome 430 2.0 Array)   1459863_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035992
Ensembl peptide - ENSMUSP00000155780
NCBI entrez gene - 106039     See in Manteia.
MGI - MGI:2146207
RefSeq - XM_017316362
RefSeq - NM_145929
RefSeq Peptide - NP_666041
swissprot - Q8R0H9
Ensembl - ENSMUSG00000033128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gga1ENSDARG00000038537Danio rerio
 GGA1ENSGALG00000039658Gallus gallus
 GGA1ENSG00000100083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*ENSMUSG0000002074055
Gga2 / Q6P5E6 / ADP-ribosylation factor-binding protein GGA2 / Q9UJY4* / golgi associated, gamma adaptin ear containing, ARF binding protein 2*ENSMUSG0000003087243
Tom1 / O88746 / target of myb1 trafficking protein / O60784* / target of myb1 membrane trafficking protein*ENSMUSG0000004287016
Q5SRX1 / Tom1l2 / TOM1-like protein 2 / Q6ZVM7* / target of myb1 like 2 membrane trafficking protein*ENSMUSG0000000053816
Q923U0 / Tom1l1 / target of myb1-like 1 (chicken) / O75674* / target of myb1 like 1 membrane trafficking protein*ENSMUSG0000002054113


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR008942  ENTH/VHS
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IGI
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030306 ADP-ribosylation factor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cisd2Gt(XS0445)Wtsi/Cisd2Gt(XS0445)Wtsi
Genetic Background: B6.129P2-Cisd2Gt(XS0445)Wtsi

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1Gt(AN0619)Wtsi,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Gga1Gt(AN0619)Wtsi/Gga1+,Gga3Gt(RRC067)Byg/Gga3Gt(RRC067)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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