ENSMUSG00000000538


Mus musculus

Features
Gene ID: ENSMUSG00000000538
  
Biological name :Tom1l2
  
Synonyms : Q5SRX1 / Tom1l2 / TOM1-like protein 2
  
Possible biological names infered from orthology : Q6ZVM7 / target of myb1 like 2 membrane trafficking protein
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 60226714
Gene end: 60352905
  
Corresponding Affymetrix probe sets: 10386495 (MoGene1.0st)   1425659_at (Mouse Genome 430 2.0 Array)   1434385_at (Mouse Genome 430 2.0 Array)   1437915_at (Mouse Genome 430 2.0 Array)   1451795_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121936
Ensembl peptide - ENSMUSP00000063414
Ensembl peptide - ENSMUSP00000090734
Ensembl peptide - ENSMUSP00000090736
Ensembl peptide - ENSMUSP00000092884
Ensembl peptide - ENSMUSP00000099743
Ensembl peptide - ENSMUSP00000099744
Ensembl peptide - ENSMUSP00000117623
NCBI entrez gene - 216810     See in Manteia.
MGI - MGI:2443306
RefSeq - XM_017314451
RefSeq - NM_001039092
RefSeq - NM_001039093
RefSeq - NM_153080
RefSeq - XM_006532861
RefSeq - XM_006532867
RefSeq - XM_011248906
RefSeq - XM_011248907
RefSeq - XM_011248908
RefSeq Peptide - NP_001034182
RefSeq Peptide - NP_694720
RefSeq Peptide - NP_001034181
swissprot - F6RBX1
swissprot - F6ZDJ1
swissprot - Q5SRX1
swissprot - Q5SXA4
swissprot - Q5SXA5
Ensembl - ENSMUSG00000000538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tom1l2ENSDARG00000009217Danio rerio
 TOM1L2ENSDARG00000056394Danio rerio
 TOM1L2ENSGALG00000004902Gallus gallus
 Q6ZVM7ENSG00000175662Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tom1 / O88746 / target of myb1 trafficking protein / O60784* / target of myb1 membrane trafficking protein*ENSMUSG0000004287061
Gga3 / Q8BMI3 / ADP-ribosylation factor-binding protein GGA3 / Q9NZ52* / golgi associated, gamma adaptin ear containing, ARF binding protein 3*ENSMUSG0000002074023
Q923U0 / Tom1l1 / target of myb1-like 1 (chicken) / O75674* / target of myb1 like 1 membrane trafficking protein*ENSMUSG0000002054123
Gga1 / Q8R0H9 / ADP-ribosylation factor-binding protein GGA1 / Q9UJY5* / golgi associated, gamma adaptin ear containing, ARF binding protein 1*ENSMUSG0000003312820
Gga2 / Q6P5E6 / ADP-ribosylation factor-binding protein GGA2 / Q9UJY4* / golgi associated, gamma adaptin ear containing, ARF binding protein 2*ENSMUSG0000003087219


Protein motifs (from Interpro)
Interpro ID Name
 IPR002014  VHS domain
 IPR004152  GAT domain
 IPR008942  ENTH/VHS
 IPR014645  Target of Myb protein 1
 IPR027429  Target of Myb1-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030276 clathrin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0004208 basal cell carcinoma "a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010357 increased prostate gland tumor incidence "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

Allelic Composition: Tom1l2Gt(XG909)Byg/Tom1l2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Ephb6tm2Tom/Ephb6tm2Tom
Genetic Background: involves: 129S4/SvJae * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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