ENSGALG00000021611


Gallus gallus

Features
Gene ID: ENSGALG00000021611
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : AC027644.4 / Q9JM13 / Q9UJ41 / Rab5 GDP/GTP exchange factor / RABGEF1 / RAB guanine nucleotide exchange factor 1
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 5026322
Gene end: 5037395
  
Corresponding Affymetrix probe sets: GgaAffx.25548.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004113
swissprot - E1C0P2
Ensembl - ENSGALG00000021611
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rabgef1ENSDARG00000014430Danio rerio
 rabgef1lENSDARG00000015968Danio rerio
 AC027644.4ENSG00000284461Homo sapiens
 Q9UJ41ENSG00000154710Homo sapiens
 Q9JM13ENSMUSG00000025340Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAPVD1 / GTPase activating protein and VPS9 domains 1 / Q14C86* / Q6PAR5* / GTPase-activating protein and VPS9 domain-containing protein 1 *ENSGALG0000000099319


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003123  VPS9 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002686 negative regulation of leukocyte migration IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033004 negative regulation of mast cell activation IEA
 biological_processGO:0043305 negative regulation of mast cell degranulation IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:1900235 negative regulation of Kit signaling pathway IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000039658 GGA1 / golgi associated, gamma adaptin ear containing, ARF binding protein 1 / Q8R0H9* / Q9UJY5* / ADP-ribosylation factor-binding protein GGA1 *  / complex
 ENSGALG00000006140 GGA2 / golgi associated, gamma adaptin ear containing, ARF binding protein 2 / Q6P5E6* / Q9UJY4* / ADP-ribosylation factor-binding protein GGA2 *  / complex
 ENSGALG00000003359 RAB5C / Q98932 / Ras-related protein Rab-5C / P51148* / P35278* / RAB5C, member RAS oncogene family*  / complex
 ENSGALG00000011272 RAB5A / RAB5A, member RAS oncogene family / P20339* / Q9CQD1* / Ras-related protein Rab-5A *  / complex
 ENSGALG00000042482 RAB5B / ras-related protein Rab-5B / P61020* / P61021* / RAB5B, member RAS oncogene family*  / complex
 ENSGALG00000039221 A6NDS4* / B9A6J9* / TBC1D3* / P0C7X1* / Q2M2D7* / Q6DHY5* / Q6IPX1* / Q8IZP1* / Q86UD7* / TBC1D3F* / TBC1D3H* / TBC1D3G* / TBC1D3I* / TBC1D3K* / TBC1D3L* / TBC1D26* / TBC1D28* / TBC1D3B* / ...  / complex / reaction






 

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