ENSMUSG00000001036


Mus musculus

Features
Gene ID: ENSMUSG00000001036
  
Biological name :Epn2
  
Synonyms : Epn2 / Epsin-2 / Q8CHU3
  
Possible biological names infered from orthology : O95208
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61517249
Gene end: 61579687
  
Corresponding Affymetrix probe sets: 10386743 (MoGene1.0st)   1427225_at (Mouse Genome 430 2.0 Array)   1427226_at (Mouse Genome 430 2.0 Array)   1433915_s_at (Mouse Genome 430 2.0 Array)   1440175_at (Mouse Genome 430 2.0 Array)   1447599_x_at (Mouse Genome 430 2.0 Array)   1454303_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136553
Ensembl peptide - ENSMUSP00000123675
Ensembl peptide - ENSMUSP00000136950
Ensembl peptide - ENSMUSP00000001063
Ensembl peptide - ENSMUSP00000104351
Ensembl peptide - ENSMUSP00000104352
Ensembl peptide - ENSMUSP00000104353
Ensembl peptide - ENSMUSP00000117389
Ensembl peptide - ENSMUSP00000122514
Ensembl peptide - ENSMUSP00000122666
NCBI entrez gene - 13855     See in Manteia.
MGI - MGI:1333766
RefSeq - XM_017314253
RefSeq - XM_006532163
RefSeq - XM_006532165
RefSeq - XM_006532166
RefSeq - XM_006532167
RefSeq - XM_006532168
RefSeq - XM_006532169
RefSeq - XM_006532170
RefSeq - XM_006532171
RefSeq - XM_011248711
RefSeq - XM_011248712
RefSeq - XM_011248713
RefSeq - XM_011248714
RefSeq - NM_001252188
RefSeq - NM_001252189
RefSeq - NM_010148
RefSeq Peptide - NP_034278
RefSeq Peptide - NP_001239117
RefSeq Peptide - NP_001239118
swissprot - A8Y5D5
swissprot - Q5NCM7
swissprot - Q8CHU3
swissprot - A8Y5D4
swissprot - Q5NCM5
swissprot - F7CD65
swissprot - Q5NCM6
swissprot - F7CUV7
swissprot - J3QNT7
Ensembl - ENSMUSG00000001036
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epn2ENSDARG00000008377Danio rerio
 EPN2ENSGALG00000035919Gallus gallus
 EPN2ENSG00000072134Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epn1 / Q80VP1 / Epsin-1 / Q9Y6I3*ENSMUSG0000003520346
Epn3 / Q91W69 / Epsin-3 / Q9H201*ENSMUSG0000001008043
Clint1 / Mus musculus clathrin interactor 1 (Clint1), transcript variant 2, mRNA. / Q14677* / clathrin interactor 1*ENSMUSG0000000616924
Enthd1 / ENTH domain containing 1 / Q8IYW4*ENSMUSG0000005043923


Protein motifs (from Interpro)
Interpro ID Name
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR013809  ENTH domain
 IPR027319  Epsin-2, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007219 Notch signaling pathway IGI
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0048568 embryonic organ development IGI
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030128 clathrin coat of endocytic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre/ERT2)CIVE23Mlia/0,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005222 abnormal somite size "atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Epn1tm1Ocr/Epn1tm1Ocr,Epn2tm1Ocr/Epn2+
Genetic Background: B6.129X1-Epn1tm1Ocr Epn2tm1Ocr

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epn1tm1.1Wami/Epn1tm1.1Wami,Epn2tm1Ocr/Epn2tm1Ocr,Tg(Cdh5-cre/ERT2)CIVE23Mlia/0,Tg(TRAMP)8247Ng/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dync2h1mmi/Dync2h1mmi,Tg(Hlxb9-GFP)1Tmj/?
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0020161 increased vascular endothelial cell proliferation "increase in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Ogg1tm1Skmi/Ogg1tm1Skmi
Genetic Background: involves: 129S/SvEv * C57BL/6JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction / complex
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / complex / reaction
 ENSMUSG00000050148 Q9QZM0 / Ubqln2 / ubiquilin 2 / Q9UHD9*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction






 

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