ENSG00000072134


Homo sapiens

Features
Gene ID: ENSG00000072134
  
Biological name :EPN2
  
Synonyms : EPN2 / epsin 2 / O95208
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 19215615
Gene end: 19336715
  
Corresponding Affymetrix probe sets: 203463_s_at (Human Genome U133 Plus 2.0 Array)   203464_s_at (Human Genome U133 Plus 2.0 Array)   241239_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463141
Ensembl peptide - ENSP00000463769
Ensembl peptide - ENSP00000463627
Ensembl peptide - ENSP00000261495
Ensembl peptide - ENSP00000320543
Ensembl peptide - ENSP00000378980
Ensembl peptide - ENSP00000378982
Ensembl peptide - ENSP00000378988
Ensembl peptide - ENSP00000378990
Ensembl peptide - ENSP00000459542
Ensembl peptide - ENSP00000459678
Ensembl peptide - ENSP00000460193
Ensembl peptide - ENSP00000462392
Ensembl peptide - ENSP00000462426
Ensembl peptide - ENSP00000462465
Ensembl peptide - ENSP00000462606
Ensembl peptide - ENSP00000462958
NCBI entrez gene - 22905     See in Manteia.
OMIM - 607263
RefSeq - NM_014964
RefSeq - NM_148921
RefSeq - NM_001102664
RefSeq Peptide - NP_001096134
RefSeq Peptide - NP_055779
RefSeq Peptide - NP_683723
swissprot - J3KSF8
swissprot - J3KSR0
swissprot - J3KTF6
swissprot - J3QKL8
swissprot - J3QLN2
swissprot - J3QQJ8
swissprot - E9PBC1
swissprot - O95208
swissprot - F6PQP6
swissprot - I3L2B2
swissprot - I3L2H1
swissprot - I3L356
swissprot - J3KSA6
swissprot - J3KSC7
Ensembl - ENSG00000072134
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epn2ENSDARG00000008377Danio rerio
 EPN2ENSGALG00000035919Gallus gallus
 Epn2ENSMUSG00000001036Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPN1 / Q9Y6I3 / epsin 1ENSG0000006324547
EPN3 / Q9H201 / epsin 3ENSG0000004928345
ENTHD1 / Q8IYW4 / ENTH domain containing 1ENSG0000017617724
CLINT1 / Q14677 / clathrin interactor 1ENSG0000011328224


Protein motifs (from Interpro)
Interpro ID Name
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR013809  ENTH domain
 IPR027319  Epsin-2, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0045747 positive regulation of Notch signaling pathway IMP
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030128 clathrin coat of endocytic vesicle IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000169891 REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000188021 Q9UHD9 / UBQLN2 / ubiquilin 2  / complex / reaction






 

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