ENSG00000063245


Homo sapiens

Features
Gene ID: ENSG00000063245
  
Biological name :EPN1
  
Synonyms : EPN1 / epsin 1 / Q9Y6I3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 55675226
Gene end: 55709858
  
Corresponding Affymetrix probe sets: 221141_x_at (Human Genome U133 Plus 2.0 Array)   223872_at (Human Genome U133 Plus 2.0 Array)   226667_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466593
Ensembl peptide - ENSP00000085079
Ensembl peptide - ENSP00000270460
Ensembl peptide - ENSP00000406209
NCBI entrez gene - 29924     See in Manteia.
OMIM - 607262
RefSeq - XM_017026725
RefSeq - XM_005258830
RefSeq - XM_011526880
RefSeq - XM_011526881
RefSeq - XM_017026722
RefSeq - XM_017026723
RefSeq - XM_017026724
RefSeq - NM_001130071
RefSeq - NM_001130072
RefSeq - NM_013333
RefSeq - XM_005258829
RefSeq Peptide - NP_037465
RefSeq Peptide - NP_001123543
RefSeq Peptide - NP_001123544
swissprot - K7EMP4
swissprot - Q9Y6I3
swissprot - A0A024R4S1
Ensembl - ENSG00000063245
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epn1ENSDARG00000010411Danio rerio
 Epn1ENSMUSG00000035203Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPN2 / O95208 / epsin 2ENSG0000007213446
EPN3 / Q9H201 / epsin 3ENSG0000004928340
ENTHD1 / Q8IYW4 / ENTH domain containing 1ENSG0000017617721
CLINT1 / Q14677 / clathrin interactor 1ENSG0000011328221


Protein motifs (from Interpro)
Interpro ID Name
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR013809  ENTH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:1903671 negative regulation of sprouting angiogenesis IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188021 Q9UHD9 / UBQLN2 / ubiquilin 2  / reaction / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000169891 REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction






 

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