ENSMUSG00000028552


Mus musculus

Features
Gene ID: ENSMUSG00000028552
  
Biological name :Eps15
  
Synonyms : Epidermal growth factor receptor substrate 15 / Eps15 / P42567
  
Possible biological names infered from orthology : epidermal growth factor receptor pathway substrate 15 / P42566
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 109280268
Gene end: 109387817
  
Corresponding Affymetrix probe sets: 10506939 (MoGene1.0st)   1419251_at (Mouse Genome 430 2.0 Array)   1419252_at (Mouse Genome 430 2.0 Array)   1430152_at (Mouse Genome 430 2.0 Array)   1440729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135755
Ensembl peptide - ENSMUSP00000135034
Ensembl peptide - ENSMUSP00000135270
Ensembl peptide - ENSMUSP00000030281
Ensembl peptide - ENSMUSP00000099790
Ensembl peptide - ENSMUSP00000118949
Ensembl peptide - ENSMUSP00000134922
NCBI entrez gene - 13858     See in Manteia.
MGI - MGI:104583
RefSeq - XM_017319956
RefSeq - NM_001159964
RefSeq - NM_007943
RefSeq - XM_006502738
RefSeq - XM_006502739
RefSeq - XM_006502740
RefSeq Peptide - NP_031969
RefSeq Peptide - NP_001153436
swissprot - Q5JC28
swissprot - H3BJB8
swissprot - H3BK65
swissprot - H3BLE4
swissprot - F6W2Q5
swissprot - A0A0R4J0A0
swissprot - Q80ZL3
swissprot - P42567
Ensembl - ENSMUSG00000028552
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps15ENSDARG00000078216Danio rerio
 EPS15ENSGALG00000010543Gallus gallus
 EPS15ENSG00000085832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q60902 / Eps15l1 / Epidermal growth factor receptor substrate 15-like 1 / Q9UBC2* / epidermal growth factor receptor pathway substrate 15 like 1*ENSMUSG0000000627648
Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*ENSMUSG0000002295723
Itsn2 / intersectin 2 / Q9NZM3*ENSMUSG0000002064022
Reps1 / O54916 / RalBP1-associated Eps domain-containing protein 1 / Q96D71* / RALBP1 associated Eps domain containing 1*ENSMUSG0000001985416
Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSMUSG0000004085514
Ehd2 / Q8BH64 / EH domain-containing protein 2 / Q9NZN4* / EH domain containing 2*ENSMUSG0000007436410
Ehd3 / Q9QXY6 / EH domain-containing protein 3 / Q9NZN3* / EH domain containing 3*ENSMUSG0000002406510
Ehd4 / Q9EQP2 / EH domain-containing protein 4 / Q9H223* / EH domain containing 4*ENSMUSG000000272939
Ehd1 / Q9WVK4 / EH domain-containing protein 1 / Q9H4M9* / EH domain containing 1*ENSMUSG000000247729
Srl / Q7TQ48 / Sarcalumenin / Q86TD4*ENSMUSG000000225197


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR003903  Ubiquitin interacting motif
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0006895 Golgi to endosome transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019065 receptor-mediated endocytosis of virus by host cell IEA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048268 clathrin coat assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IDA
 cellular_componentGO:0030132 clathrin coat of coated pit IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0060170 ciliary membrane IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Myo5btm1.1Cle/Myo5btm1.1Cle,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ehd1tm1a(EUCOMM)Wtsi/Ehd1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ehd1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Eps15tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Eps15tm1a(KOMP)Wtsi/Eps15tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Tead4tm1Hssk/Tead4tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * DBA)

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Eps15tm1Noff/Eps15tm1Noff
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / complex
 ENSMUSG00000040855 Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*  / reaction / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000050148 Q9QZM0 / Ubqln2 / ubiquilin 2 / Q9UHD9*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / reaction / complex
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction / complex
 ENSMUSG00000055371 Stam2 / O88811 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / signal transducing adaptor molecule 2*  / complex






 

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