ENSMUSG00000020640


Mus musculus

Features
Gene ID: ENSMUSG00000020640
  
Biological name :Itsn2
  
Synonyms : intersectin 2 / Itsn2
  
Possible biological names infered from orthology : Q9NZM3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 4592638
Gene end: 4713962
  
Corresponding Affymetrix probe sets: 10394288 (MoGene1.0st)   1423184_at (Mouse Genome 430 2.0 Array)   1431772_a_at (Mouse Genome 430 2.0 Array)   1435023_at (Mouse Genome 430 2.0 Array)   1445375_at (Mouse Genome 430 2.0 Array)   1446595_at (Mouse Genome 430 2.0 Array)   1446735_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151561
Ensembl peptide - ENSMUSP00000151900
Ensembl peptide - ENSMUSP00000151896
Ensembl peptide - ENSMUSP00000151663
Ensembl peptide - ENSMUSP00000052758
NCBI entrez gene - 20403     See in Manteia.
MGI - MGI:1338049
RefSeq - XM_006515027
RefSeq - XM_006515023
RefSeq - XM_006515026
RefSeq - XM_006515025
RefSeq - NM_001198968
RefSeq - NM_011365
RefSeq - XM_006515024
RefSeq Peptide - NP_001185897
RefSeq Peptide - NP_035495
swissprot - E9QNG1
swissprot - A0A1W2P775
swissprot - A0A1W2P7G8
swissprot - B2RR82
Ensembl - ENSMUSG00000020640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itsn2aENSDARG00000000161Danio rerio
 itsn2bENSDARG00000054973Danio rerio
 ITSN2ENSGALG00000016504Gallus gallus
 ITSN2ENSG00000198399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*ENSMUSG0000002295761
Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*ENSMUSG0000002855212
Q60902 / Eps15l1 / Epidermal growth factor receptor substrate 15-like 1 / Q9UBC2* / epidermal growth factor receptor pathway substrate 15 like 1*ENSMUSG0000000627612
Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSMUSG000000408557
Reps1 / O54916 / RalBP1-associated Eps domain-containing protein 1 / Q96D71* / RALBP1 associated Eps domain containing 1*ENSMUSG000000198547
Ehd2 / Q8BH64 / EH domain-containing protein 2 / Q9NZN4* / EH domain containing 2*ENSMUSG000000743646
Ehd3 / Q9QXY6 / EH domain-containing protein 3 / Q9NZN3* / EH domain containing 3*ENSMUSG000000240656
Ehd4 / Q9EQP2 / EH domain-containing protein 4 / Q9H223* / EH domain containing 4*ENSMUSG000000272935
Ehd1 / Q9WVK4 / EH domain-containing protein 1 / Q9H4M9* / EH domain containing 1*ENSMUSG000000247725
Srl / Q7TQ48 / Sarcalumenin / Q86TD4*ENSMUSG000000225193


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000219  Dbl homology (DH) domain
 IPR000261  EH domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR027029  Intersectin-2
 IPR035737  Intersectin-2, first SH3 domain
 IPR035738  Intersectin-2, second SH3 domain
 IPR035739  Intersectin-2, third SH3 domain
 IPR035740  Intersectin-2, fourth SH3 domain
 IPR035741  Intersectin-2, fifth SH3 domain
 IPR035892  C2 domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz,Itsn2tm1Egan/Itsn2tm1Egan
Genetic Background: involves: 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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