ENSG00000198399


Homo sapiens

Features
Gene ID: ENSG00000198399
  
Biological name :ITSN2
  
Synonyms : intersectin 2 / ITSN2 / Q9NZM3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.3
Gene start: 24202864
Gene end: 24360714
  
Corresponding Affymetrix probe sets: 209898_x_at (Human Genome U133 Plus 2.0 Array)   209907_s_at (Human Genome U133 Plus 2.0 Array)   210545_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411319
Ensembl peptide - ENSP00000479408
Ensembl peptide - ENSP00000384499
Ensembl peptide - ENSP00000354561
Ensembl peptide - ENSP00000347244
Ensembl peptide - ENSP00000391715
Ensembl peptide - ENSP00000395682
Ensembl peptide - ENSP00000389013
Ensembl peptide - ENSP00000391224
NCBI entrez gene - 50618     See in Manteia.
OMIM - 604464
RefSeq - NM_006277
RefSeq - NM_147152
RefSeq - NM_001348181
RefSeq - NM_019595
RefSeq Peptide - NP_006268
RefSeq Peptide - NP_001335110
RefSeq Peptide - NP_671494
RefSeq Peptide - NP_062541
swissprot - Q9NZM3
swissprot - A0A087WVF7
swissprot - E7EPJ2
swissprot - F8W719
swissprot - H7BZD4
swissprot - H7C0L8
swissprot - H7C3E2
Ensembl - ENSG00000198399
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itsn2aENSDARG00000000161Danio rerio
 itsn2bENSDARG00000054973Danio rerio
 ITSN2ENSGALG00000016504Gallus gallus
 Itsn2ENSMUSG00000020640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITSN1 / Q15811 / intersectin 1ENSG0000020572661
Q9UBC2 / EPS15L1 / epidermal growth factor receptor pathway substrate 15 like 1ENSG0000012752712
EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15ENSG0000008583212
REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2ENSG000001698917
REPS1 / Q96D71 / RALBP1 associated Eps domain containing 1ENSG000001355977
EHD3 / Q9NZN3 / EH domain containing 3ENSG000000130166
EHD2 / Q9NZN4 / EH domain containing 2ENSG000000244226
EHD4 / Q9H223 / EH domain containing 4ENSG000001039665
EHD1 / Q9H4M9 / EH domain containing 1ENSG000001100475
SRL / Q86TD4 / sarcalumeninENSG000001857393


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000219  Dbl homology (DH) domain
 IPR000261  EH domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR018247  EF-Hand 1, calcium-binding site
 IPR027029  Intersectin-2
 IPR035737  Intersectin-2, first SH3 domain
 IPR035738  Intersectin-2, second SH3 domain
 IPR035739  Intersectin-2, third SH3 domain
 IPR035740  Intersectin-2, fourth SH3 domain
 IPR035741  Intersectin-2, fifth SH3 domain
 IPR035892  C2 domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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