ENSG00000103966


Homo sapiens

Features
Gene ID: ENSG00000103966
  
Biological name :EHD4
  
Synonyms : EHD4 / EH domain containing 4 / Q9H223
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.1
Gene start: 41895939
Gene end: 41972578
  
Corresponding Affymetrix probe sets: 1556607_at (Human Genome U133 Plus 2.0 Array)   1556608_a_at (Human Genome U133 Plus 2.0 Array)   209536_s_at (Human Genome U133 Plus 2.0 Array)   229074_at (Human Genome U133 Plus 2.0 Array)   233660_at (Human Genome U133 Plus 2.0 Array)   237097_at (Human Genome U133 Plus 2.0 Array)   239472_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000220325
NCBI entrez gene - 30844     See in Manteia.
OMIM - 605892
RefSeq - XM_017022100
RefSeq - NM_139265
RefSeq Peptide - NP_644670
swissprot - Q9H223
swissprot - A0A024R9N6
Ensembl - ENSG00000103966
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ehd4ENSDARG00000054302Danio rerio
 EHD4ENSGALG00000008950Gallus gallus
 Ehd4ENSMUSG00000027293Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EHD3 / Q9NZN3 / EH domain containing 3ENSG0000001301674
EHD1 / Q9H4M9 / EH domain containing 1ENSG0000011004774
EHD2 / Q9NZN4 / EH domain containing 2ENSG0000002442269
SRL / Q86TD4 / sarcalumeninENSG0000018573923
ITSN2 / Q9NZM3 / intersectin 2ENSG0000019839917
ITSN1 / Q15811 / intersectin 1ENSG0000020572617
EPS15 / P42566 / epidermal growth factor receptor pathway substrate 15ENSG0000008583216
Q9UBC2 / EPS15L1 / epidermal growth factor receptor pathway substrate 15 like 1ENSG0000012752716
REPS1 / Q96D71 / RALBP1 associated Eps domain containing 1ENSG0000013559710
REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2ENSG000001698919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029952  EH domain-containing protein 4
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain
 IPR031692  EH domain-containing protein, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006907 pinocytosis IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0032456 endocytic recycling IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051260 protein homooligomerization IPI
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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