ENSG00000085832


Homo sapiens

Features
Gene ID: ENSG00000085832
  
Biological name :EPS15
  
Synonyms : epidermal growth factor receptor pathway substrate 15 / EPS15 / P42566
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.3
Gene start: 51354263
Gene end: 51519328
  
Corresponding Affymetrix probe sets: 217886_at (Human Genome U133 Plus 2.0 Array)   217887_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474739
Ensembl peptide - ENSP00000360795
Ensembl peptide - ENSP00000360798
NCBI entrez gene - 2060     See in Manteia.
OMIM - 600051
RefSeq - XM_017000620
RefSeq - NM_001981
RefSeq - XM_017000616
RefSeq - XM_017000617
RefSeq - XM_017000618
RefSeq - XM_017000619
RefSeq - XM_005270618
RefSeq - XM_017000615
RefSeq Peptide - NP_001972
swissprot - P42566
swissprot - S4R3U1
swissprot - B1AUU8
Ensembl - ENSG00000085832
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps15ENSDARG00000078216Danio rerio
 EPS15ENSGALG00000010543Gallus gallus
 Eps15ENSMUSG00000028552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UBC2 / EPS15L1 / epidermal growth factor receptor pathway substrate 15 like 1ENSG0000012752749
ITSN2 / Q9NZM3 / intersectin 2ENSG0000019839922
ITSN1 / Q15811 / intersectin 1ENSG0000020572622
REPS1 / Q96D71 / RALBP1 associated Eps domain containing 1ENSG0000013559716
REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2ENSG0000016989114
EHD3 / Q9NZN3 / EH domain containing 3ENSG0000001301610
EHD1 / Q9H4M9 / EH domain containing 1ENSG000001100479
EHD2 / Q9NZN4 / EH domain containing 2ENSG000000244229
EHD4 / Q9H223 / EH domain containing 4ENSG000001039669
SRL / Q86TD4 / sarcalumeninENSG000001857396


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR003903  Ubiquitin interacting motif
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0006895 Golgi to endosome transport IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016050 vesicle organization TAS
 biological_processGO:0019065 receptor-mediated endocytosis of virus by host cell IMP
 biological_processGO:0032456 endocytic recycling IC
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0046718 viral entry into host cell IMP
 biological_processGO:0048268 clathrin coat assembly IDA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005905 clathrin-coated pit TAS
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000115145 STAM2 / O75886 / signal transducing adaptor molecule 2  / complex
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000169891 REPS2 / Q8NFH8 / RALBP1 associated Eps domain containing 2  / complex / reaction
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000188021 Q9UHD9 / UBQLN2 / ubiquilin 2  / complex / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex
 ENSG00000185359 HGS / O14964 / hepatocyte growth factor-regulated tyrosine kinase substrate  / complex
 ENSG00000147010 Q96B97 / SH3KBP1 / SH3 domain containing kinase binding protein 1  / complex / reaction
 ENSG00000136738 STAM / Q92783 / signal transducing adaptor molecule  / complex
 ENSG00000107295 Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1  / reaction / complex






 

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