ENSMUSG00000074364


Mus musculus

Features
Gene ID: ENSMUSG00000074364
  
Biological name :Ehd2
  
Synonyms : Ehd2 / EH domain-containing protein 2 / Q8BH64
  
Possible biological names infered from orthology : EH domain containing 2 / Q9NZN4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 15946958
Gene end: 15967567
  
Corresponding Affymetrix probe sets: 10560190 (MoGene1.0st)   1424157_at (Mouse Genome 430 2.0 Array)   1424158_at (Mouse Genome 430 2.0 Array)   1427729_at (Mouse Genome 430 2.0 Array)   1435785_at (Mouse Genome 430 2.0 Array)   1459823_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119933
Ensembl peptide - ENSMUSP00000096397
NCBI entrez gene - 259300     See in Manteia.
MGI - MGI:2154274
RefSeq - NM_153068
RefSeq - XM_011250582
RefSeq Peptide - NP_694708
swissprot - D3Z7U7
swissprot - Q8BH64
Ensembl - ENSMUSG00000074364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ehd2aENSDARG00000035137Danio rerio
 ehd2bENSDARG00000040362Danio rerio
 EHD2ENSG00000024422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ehd3 / Q9QXY6 / EH domain-containing protein 3 / Q9NZN3* / EH domain containing 3*ENSMUSG0000002406571
Ehd1 / Q9WVK4 / EH domain-containing protein 1 / Q9H4M9* / EH domain containing 1*ENSMUSG0000002477270
Ehd4 / Q9EQP2 / EH domain-containing protein 4 / Q9H223* / EH domain containing 4*ENSMUSG0000002729368
Srl / Q7TQ48 / Sarcalumenin / Q86TD4*ENSMUSG0000002251925
Itsn2 / intersectin 2 / Q9NZM3*ENSMUSG0000002064018
Q60902 / Eps15l1 / Epidermal growth factor receptor substrate 15-like 1 / Q9UBC2* / epidermal growth factor receptor pathway substrate 15 like 1*ENSMUSG0000000627617
Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*ENSMUSG0000002295717
Eps15 / P42567 / Epidermal growth factor receptor substrate 15 / P42566* / epidermal growth factor receptor pathway substrate 15*ENSMUSG0000002855216
Reps1 / O54916 / RalBP1-associated Eps domain-containing protein 1 / Q96D71* / RALBP1 associated Eps domain containing 1*ENSMUSG0000001985410
Reps2 / RALBP1 associated Eps domain containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSMUSG0000004085510


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029945  EH domain-containing protein 2
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain
 IPR031692  EH domain-containing protein, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030866 cortical actin cytoskeleton organization IDA
 biological_processGO:0032456 endocytic recycling IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0097320 plasma membrane tubulation IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:2001137 positive regulation of endocytic recycling IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0045171 intercellular bridge IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014550 Rbsn / Q80Y56 / Rabenosyn-5 / Q9H1K0* / rabenosyn, RAB effector*  / complex / reaction






 

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