ENSGALG00000007224


Gallus gallus

Features
Gene ID: ENSGALG00000007224
  
Biological name :HGS
  
Synonyms : hepatocyte growth factor-regulated tyrosine kinase substrate / HGS
  
Possible biological names infered from orthology : hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 / O14964
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 9972756
Gene end: 9981924
  
Corresponding Affymetrix probe sets: Gga.7570.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011677
NCBI entrez gene - 428675     See in Manteia.
RefSeq - XM_015295556
RefSeq - XM_015295557
swissprot - E1C396
Ensembl - ENSGALG00000007224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hgsENSDARG00000020960Danio rerio
 HGSENSG00000185359Homo sapiens
 HgsENSMUSG00000116045Mus musculus
 HgsENSMUSG00000025793Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANKFY1 / ankyrin repeat and FYVE domain containing 1 / Q810B6* / Q9P2R3* / Rabankyrin-5 *ENSGALG0000000146717
ENSGALG000000415937


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017073  Ubiquitin binding protein, Hrs/VPS27
 IPR017455  Zinc finger, FYVE-related
 IPR024641  Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006622 protein targeting to lysosome IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0010324 membrane invagination IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0043405 regulation of MAP kinase activity IEA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033565 ESCRT-0 complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex / reaction
 ENSGALG00000006312 TSG101 / tumor susceptibility 101 / Q61187* / Q99816* / tumor susceptibility gene 101*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSGALG00000003743 VPS37B / VPS37B, ESCRT-I subunit / Q8R0J7* / Q9H9H4* / vacuolar protein sorting 37B*  / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000013646 VPS37A / VPS37A, ESCRT-I subunit / Q8CHS8* / Q8NEZ2* / vacuolar protein sorting 37A*  / reaction
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000000950 MVB12B / multivesicular body subunit 12B / Q6KAU4* / Q9H7P6*  / reaction
 ENSGALG00000038541 VPS37C / vacuolar protein sorting-associated protein 37C / Q8R105* / A5D8V6* / VPS37C, ESCRT-I subunit* / vacuolar protein sorting 37C*  / reaction
 ENSGALG00000035287 STAM / signal transducing adaptor molecule / P70297* / Q92783* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / complex






 

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