ENSGALG00000035287


Gallus gallus

Features
Gene ID: ENSGALG00000035287
  
Biological name :STAM
  
Synonyms : signal transducing adaptor molecule / STAM
  
Possible biological names infered from orthology : P70297 / Q92783 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 19670926
Gene end: 19700789
  
Corresponding Affymetrix probe sets: Gga.10633.1.S1_at (Chicken Array)   Gga.14766.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043582
NCBI entrez gene - 420517     See in Manteia.
RefSeq - XM_015282001
swissprot - A0A1D5NTC8
Ensembl - ENSGALG00000035287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stamENSDARG00000002127Danio rerio
 STAMENSG00000136738Homo sapiens
 StamENSMUSG00000026718Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAM2 / signal transducing adapter molecule 2 / O88811* / O75886* / signal transducing adaptor molecule 2* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2*ENSGALG0000001251353


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002014  VHS domain
 IPR003903  Ubiquitin interacting motif
 IPR008942  ENTH/VHS


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:1903543 positive regulation of exosomal secretion IEA
 biological_processGO:1903551 regulation of extracellular exosome assembly IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0033565 ESCRT-0 complex IEA
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Metalloprotease DUBs
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Endosomal Sorting Complex Required For Transport (ESCRT)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000013646 VPS37A / VPS37A, ESCRT-I subunit / Q8CHS8* / Q8NEZ2* / vacuolar protein sorting 37A*  / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000000950 MVB12B / multivesicular body subunit 12B / Q6KAU4* / Q9H7P6*  / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000006312 TSG101 / tumor susceptibility 101 / Q61187* / Q99816* / tumor susceptibility gene 101*  / reaction
 ENSGALG00000003743 VPS37B / VPS37B, ESCRT-I subunit / Q8R0J7* / Q9H9H4* / vacuolar protein sorting 37B*  / reaction
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex / reaction
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex
 ENSGALG00000038541 VPS37C / vacuolar protein sorting-associated protein 37C / Q8R105* / A5D8V6* / VPS37C, ESCRT-I subunit* / vacuolar protein sorting 37C*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex






 

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