| MP:0000753 | paralysis | "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000846 | abnormal medulla oblongata | "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000930 | wavy neural tube | "undulations in the embryonic neural tube" [J:37888] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000952 | abnormal CNS glia | "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0000956 | reduced spinal cord size | "smaller appearance of the spinal cord" [J:35802] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001077 | abnormal spinal nerve morphology | "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001255 | decreased body height | "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J
|
| MP:0001388 | abnormal stationary movement | "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
|
| MP:0001409 | increased stereotypic behavior | "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
|
| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001522 | impaired swimming | "reduced ability or inability to swim" [J:45446, J:39081] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001688 | abnormal somite development | "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0001924 | infertility | "inability to produce live offspring" [J:47225] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002086 | abnormal extraembryonic tissue morphology | "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0002573 | behavioral despair | "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395] |
Show
Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0002880 | opisthotonus | "a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0003062 | abnormal coping response | "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hellstm1a(EUCOMM)Wtsi/Hellstm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hellstm1a(EUCOMM)Wtsi/Ieg
|
| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0003225 | axonal dystrophy | "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0004000 | impaired passive avoidance behavior | "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0004097 | abnormal cerebellar cortex morphology | "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0004180 | failure of initiation of embryo turning | "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J
|
| MP:0004187 | cardia bifida | "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004557 | dilated allantois | "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0004601 | abnormal vertebral spinous process | "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0004706 | short vertebral body | "reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
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| MP:0005221 | abnormal rostral-caudal axis patterning | "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0005424 | jerky movement | "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Bicc1jcpk/Bicc1jcpk-bpk
Genetic Background: involves: 101 * BALB/c * C3H * C57BL/6J * T STOCK
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| MP:0006099 | thin granule layer | "reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0006205 | embryonic lethality before somite formation | "death anytime after implantation but before somite formation (E4.5 to less than E8)" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ehmt1Tg(Tyr)2265COve/Ehmt1Tg(Tyr)2265COve
Genetic Background: FVB/N-Ehmt1Tg(Tyr)2265COve
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| MP:0008027 | abnormal spinal cord white matter morphology | "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
|
| MP:0008503 | abnormal spinal cord gray matter morphology | "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0008948 | decreased neuron number | "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
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| MP:0009346 | decreased cancellous bone thickness | "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
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| MP:0009393 | abnormal resting posture | "atypical position of the limbs compared to normal carriage when the body is inactive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
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| MP:0009657 | failure of chorioallantoic fusion | "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0009940 | abnormal hippocampus pyramidal cell morphology | "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tyrc-2CHLb/Tyrc-202G
Genetic Background: involves: 101/Rl * C3H/Rl
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Hgstm1Sug/Hgstm1Sug
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hgstm1Tkh/Hgstm1Tkh
Genetic Background: involves: 129S4/SvJae * C57BL/6
|
| MP:0012083 | absent foregut | "absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder" [MGI:anna] |
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0012089 | decreased midbrain size | "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
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| MP:0012263 | decreased hindbrain size | "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
| MP:0012484 | decreased corticospinal tract size | "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
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| MP:0020533 | decreased pons size | "decreased size of or number of the nerve fibers in the pons" [MGI:smb] |
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn
|
