ENSMUSG00000006906


Mus musculus

Features
Gene ID: ENSMUSG00000006906
  
Biological name :Stambp
  
Synonyms : Q9CQ26 / STAM-binding protein / Stambp
  
Possible biological names infered from orthology : O95630
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83543211
Gene end: 83572729
  
Corresponding Affymetrix probe sets: 10545720 (MoGene1.0st)   1416317_a_at (Mouse Genome 430 2.0 Array)   1431962_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070876
Ensembl peptide - ENSMUSP00000145871
Ensembl peptide - ENSMUSP00000146294
NCBI entrez gene - 70527     See in Manteia.
MGI - MGI:1917777
RefSeq - XM_006506585
RefSeq - NM_024239
RefSeq - XM_006506583
RefSeq - XM_006506584
RefSeq Peptide - NP_077201
swissprot - Q9CQ26
Ensembl - ENSMUSG00000006906
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stambpaENSDARG00000054501Danio rerio
 stambpbENSDARG00000086906Danio rerio
 STAMBPENSGALG00000042555Gallus gallus
 O95630ENSG00000124356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q76N33 / Stambpl1 / AMSH-like protease / Q96FJ0* / STAM binding protein like 1*ENSMUSG0000002477652


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR015063  USP8 dimerisation domain
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0046580 negative regulation of Ras protein signal transduction ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032154 cleavage furrow ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Badtm1Meg/Badtm1Meg
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026718 Stam / P70297 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 / Q92783* / signal transducing adaptor molecule*  / complex / reaction






 

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