ENSMUSG00000037415


Mus musculus

Features
Gene ID: ENSMUSG00000037415
  
Biological name :Ranbp10
  
Synonyms : RAN binding protein 10 / Ranbp10
  
Possible biological names infered from orthology : Q6VN20
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 105768308
Gene end: 105827350
  
Corresponding Affymetrix probe sets: 10581340 (MoGene1.0st)   1424584_a_at (Mouse Genome 430 2.0 Array)   1424585_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040045
NCBI entrez gene - 74334     See in Manteia.
MGI - MGI:1921584
RefSeq - XM_011248526
RefSeq - NM_145824
RefSeq - XM_006531426
RefSeq Peptide - NP_665823
swissprot - A0A0R4J0G4
Ensembl - ENSMUSG00000037415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ranbp10ENSDARG00000062138Danio rerio
 RANBP10ENSGALG00000001439Gallus gallus
 Q6VN20ENSG00000141084Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P69566 / Ranbp9 / Ran-binding protein 9 / Q96S59*ENSMUSG0000003854666
Spryd3 / SPRY domain containing 3 / Q8NCJ5*ENSMUSG0000003696613


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR006594  LIS1 homology motif
 IPR006595  CTLH, C-terminal LisH motif
 IPR013144  CRA domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR024964  CTLH/CRA C-terminal to LisH motif domain
 IPR035782  Ran binding protein 9/10, SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0003405 abnormal platelet shape 
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0009446 abnormal platelet dense granule physiology "any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction






 

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