ENSMUSG00000038546


Mus musculus

Features
Gene ID: ENSMUSG00000038546
  
Biological name :Ranbp9
  
Synonyms : P69566 / Ran-binding protein 9 / Ranbp9
  
Possible biological names infered from orthology : Q96S59
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A4
Gene start: 43402675
Gene end: 43481282
  
Corresponding Affymetrix probe sets: 10408882 (MoGene1.0st)   1422736_at (Mouse Genome 430 2.0 Array)   1456199_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130636
Ensembl peptide - ENSMUSP00000152869
Ensembl peptide - ENSMUSP00000152620
Ensembl peptide - ENSMUSP00000152415
Ensembl peptide - ENSMUSP00000152113
Ensembl peptide - ENSMUSP00000152077
NCBI entrez gene - 56705     See in Manteia.
MGI - MGI:1928741
RefSeq - NM_019930
RefSeq Peptide - NP_064314
swissprot - A0A1Y7VLC4
swissprot - A0A1Y7VIP5
swissprot - E9Q5D6
swissprot - P69566
swissprot - A0A1Y7VP77
swissprot - A0A1Y7VLX7
Ensembl - ENSMUSG00000038546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ranbp9ENSDARG00000061048Danio rerio
 RANBP9ENSGALG00000012696Gallus gallus
 Q96S59ENSG00000010017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ranbp10 / RAN binding protein 10 / Q6VN20*ENSMUSG0000003741560
Spryd3 / SPRY domain containing 3 / Q8NCJ5*ENSMUSG0000003696613


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR006594  LIS1 homology motif
 IPR006595  CTLH, C-terminal LisH motif
 IPR013144  CRA domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR024964  CTLH/CRA C-terminal to LisH motif domain
 IPR035782  Ran binding protein 9/10, SPRY domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008536 Ran GTPase binding ISO
 molecular_functionGO:0019899 enzyme binding ISO


Pathways (from Reactome)
Pathway description
L1CAM interactions
RAF/MAP kinase cascade
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0009248 small caput "decrease in the average size of the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ranbp9tm1.1Wyan/Ranbp9tm1.1Wyan
Genetic Background: Not Specified

 MP:0011125 decreased primary ovarian follicle number "fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
Show

Allelic Composition: Amelxtm1Kul/Amelxtm1Kul,Tg(AMELX*P70T)2Gibs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Ranbp9tm1Wyan/Ranbp9tm1Wyan,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6J * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction






 

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