Manteia - Molecule gene

ENSMUSG00000030029

Mus musculus

Features

Gene ID:	ENSMUSG00000030029

Biological name :	Lrig1

Synonyms :	Leucine-rich repeats and immunoglobulin-like domains protein 1 / Lrig1 / P70193

Possible biological names infered from orthology :	leucine rich repeats and immunoglobulin like domains 1 / Q96JA1

Species:	Mus musculus

Chr. number:	6
Strand:	-1
Band:	D2
Gene start:	94604529
Gene end:	94700158

Corresponding Affymetrix probe sets:	10546510 (MoGene1.0st) 1419928_at (Mouse Genome 430 2.0 Array) 1434210_s_at (Mouse Genome 430 2.0 Array) 1449893_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000032105 Ensembl peptide - ENSMUSP00000098686 Ensembl peptide - ENSMUSP00000144963 NCBI entrez gene - 16206 See in Manteia. MGI - MGI:107935 RefSeq - XM_006505622 RefSeq - NM_008377 RefSeq - XM_006505621 RefSeq Peptide - NP_032403 swissprot - P70193 Ensembl - ENSMUSG00000030029

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lrig1	ENSDARG00000075625	Danio rerio
LRIG1	ENSGALG00000007483	Gallus gallus
LRIG1	ENSG00000144749	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lrig3 / Q6P1C6 / Leucine-rich repeats and immunoglobulin-like domains protein 3 / Q6UXM1* / leucine rich repeats and immunoglobulin like domains 3*	ENSMUSG00000020105	50
Lrig2 / Q52KR2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898*	ENSMUSG00000032913	46
Adgra2 / Q91ZV8 / Adhesion G protein-coupled receptor A2 / Q96PE1*	ENSMUSG00000031486	16
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*	ENSMUSG00000029090	15
Vasn / Q9CZT5 / vasorin / Q6EMK4*	ENSMUSG00000039646	14
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*	ENSMUSG00000033595	11
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*	ENSMUSG00000067242	11
Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*	ENSMUSG00000036560	9
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*	ENSMUSG00000039252	9
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*	ENSMUSG00000025475	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000372	Leucine-rich repeat N-terminal domain
IPR000483	Cysteine-rich flanking region, C-terminal
IPR001611	Leucine-rich repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013098	Immunoglobulin I-set
IPR013783	Immunoglobulin-like fold
IPR032675	Leucine-rich repeat domain superfamily
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0022405	hair cycle process	IMP
biological_process	GO:0032474	otolith morphogenesis	IGI
biological_process	GO:0060384	innervation	IGI
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

Signaling by EGFR

Negative regulation of MET activity

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000037	abnormal lateral semicircular canal	"anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0000384	distorted hair follicle pattern	"twisted or contorted configuration of the arrangement of hair follicles in the skin" [J:56777]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000490	abnormal crypts of Lieberkuhn morphology	"malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Trim72^tm1Ygko/Trim72^tm1Ygko Genetic Background: Not Specified
MP:0000588	thick tail	"a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2⁺ Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}
MP:0001191	abnormal skin condition	"anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Lrig1^{tm1a(EUCOMM)Wtsi} Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001193	psoriasis	"chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Lrig1^{tm1a(EUCOMM)Wtsi}
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001231	abnormal basal cell layer morphology	"structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Washc1^tm1Xya/Washc1^tm1Xya Genetic Background: involves: 129
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0002060	abnormal skin morphology	"malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trim72^tm1Ygko/Trim72^tm1Ygko Genetic Background: Not Specified
MP:0002404	intestinal adenoma	"benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺,Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1^{tm1.1(cre/ERT2)Rjc} Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 Allelic Composition: Apc^tm2.1Cip/Apc⁺,Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1⁺ Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002656	abnormal keratinocyte differentiation	"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002858	abnormal posterior semicircular canal	"anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0002942	decreased circulating alanine transaminase level	"decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0003164	reduced size of posterior semicircular canal		Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0003427	parakeratosis	"abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004425	abnormal otolith organ	"any structural abnormality in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Washc1^tm1Xya/Washc1^tm1Xya Genetic Background: involves: 129 Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2^{Gt(RST656)Byg} Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex} Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2⁺ Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}
MP:0004738	abnormal brainstem auditory evoked potential	"anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0005632	decreased circulating aspartate transaminase level	"less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0008861	abnormal hair shedding	"anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0009583	increased keratinocyte proliferation	"increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxc8^tm1.1Rud/Hoxc8^tm1.1Rud Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kptn^{tm1a(EUCOMM)Wtsi}/Kptn^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Kptn^{tm1a(EUCOMM)Wtsi}/Wtsi Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0010678	abnormal skin adnexa morphology	"any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6 * C57BL/6N
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0011238	abnormal inner ear development	"atypical initial production, differentiation, migration or maturation of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:llw2]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0011966	abnormal auditory brainstem response waveform shape	"any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]	Show Allelic Composition: Washc1^tm1Xya/Washc1^tm1Xya Genetic Background: involves: 129 Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2^{Gt(RST656)Byg} Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Washc1^tm1Xya/Washc1^tm1Xya Genetic Background: involves: 129 Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2^{Gt(RST656)Byg} Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex} Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig2^{Gt(RST656)Byg}/Lrig2⁺ Genetic Background: B6N.129-Lrig2^{Gt(RST656)Byg} Lrig1^{Gt(GST4169C6)Lex}

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000009376	Met / MET proto-oncogene, receptor tyrosine kinase / P08581*	/ complex / reaction
ENSMUSG00000027363	Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*	/ reaction

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