ENSMUSG00000031486


Mus musculus

Features
Gene ID: ENSMUSG00000031486
  
Biological name :Adgra2
  
Synonyms : Adgra2 / Adhesion G protein-coupled receptor A2 / Q91ZV8
  
Possible biological names infered from orthology : Q96PE1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 27085583
Gene end: 27123436
  
Corresponding Affymetrix probe sets: 10571142 (MoGene1.0st)   1418379_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033876
Ensembl peptide - ENSMUSP00000136277
Ensembl peptide - ENSMUSP00000137181
Ensembl peptide - ENSMUSP00000137457
NCBI entrez gene - 78560     See in Manteia.
MGI - MGI:1925810
RefSeq - XM_006509224
RefSeq - NM_054044
RefSeq - XM_006509222
RefSeq - XM_006509223
RefSeq Peptide - NP_473385
swissprot - Q91ZV8
swissprot - J3QPS6
swissprot - J3QPB6
swissprot - J3QMG7
Ensembl - ENSMUSG00000031486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgra2ENSDARG00000076994Danio rerio
 ADGRA2ENSGALG00000003118Gallus gallus
 ADGRA2ENSG00000020181Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*ENSMUSG0000002909042
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*ENSMUSG0000002547515
Lrig3 / Q6P1C6 / Leucine-rich repeats and immunoglobulin-like domains protein 3 / Q6UXM1* / leucine rich repeats and immunoglobulin like domains 3*ENSMUSG0000002010514
Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*ENSMUSG0000003002913
Lrig2 / Q52KR2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898*ENSMUSG0000003291313
Vasn / Q9CZT5 / vasorin / Q6EMK4*ENSMUSG000000396469
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*ENSMUSG000000335957
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*ENSMUSG000000392526
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*ENSMUSG000000672426
Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*ENSMUSG000000365606


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000832  GPCR, family 2, secretin-like
 IPR001611  Leucine-rich repeat
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0050920 regulation of chemotaxis IMP
 biological_processGO:0090210 regulation of establishment of blood-brain barrier IMP
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Neurod1tm1Mjts/Neurod1tm1Mjts
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg,Tg(Nanog-cre)#Vlcg/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Adgra2tm1Cjku/Adgra2tm2Cjku,Tg(Pdgfb-icre/ERT2)1Frut/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0004171 abnormal pallium development "anomaly in the progression of the formation of the roof region of the telencephalon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Adgra2tm1.1Bstc/Adgra2tm1.2Bstc,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Adgra2tm1.1Bstc/Adgra2tm1.2Bstc Tg(Tek-cre)12Flv

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grb2tm1Lnit/Grb2tm1Lnit,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * BALB/cJ

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0006088 abnormal blood-cerebrospinal fluid barrier "anomaly in the structure or function of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92788]
Show

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Adgra2tm1.1Vlcg/Adgra2tm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

 MP:0012732 abnormal perineural vascular plexus morphology "any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen" [MGI:anna]
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Allelic Composition: Cbstm1Unc/Cbstm1Unc
Genetic Background: B6.129P2-Cbstm1Unc/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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