ENSMUSG00000039646


Mus musculus

Features
Gene ID: ENSMUSG00000039646
  
Biological name :Vasn
  
Synonyms : Q9CZT5 / Vasn / vasorin
  
Possible biological names infered from orthology : Q6EMK4
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 4639941
Gene end: 4650802
  
Corresponding Affymetrix probe sets: 10433274 (MoGene1.0st)   1427894_at (Mouse Genome 430 2.0 Array)   1455812_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045162
NCBI entrez gene - 246154     See in Manteia.
MGI - MGI:2177651
RefSeq - NM_139307
RefSeq Peptide - NP_647468
swissprot - Q9CZT5
Ensembl - ENSMUSG00000039646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vasnaENSDARG00000099266Danio rerio
 vasnbENSDARG00000102565Danio rerio
 VASNENSG00000168140Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*ENSMUSG0000003002923
Lrig2 / Q52KR2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898*ENSMUSG0000003291322
Lrig3 / Q6P1C6 / Leucine-rich repeats and immunoglobulin-like domains protein 3 / Q6UXM1* / leucine rich repeats and immunoglobulin like domains 3*ENSMUSG0000002010521
Adgra2 / Q91ZV8 / Adhesion G protein-coupled receptor A2 / Q96PE1*ENSMUSG0000003148618
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*ENSMUSG0000002909016
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*ENSMUSG0000003359512
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*ENSMUSG0000006724211
Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*ENSMUSG0000003656011
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*ENSMUSG0000003925210
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*ENSMUSG000000254755


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013032  EGF-like, conserved site
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0071456 cellular response to hypoxia IMP
 biological_processGO:0071461 cellular response to redox state IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008406 increased cellular sensitivity to hydrogen peroxide "greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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