ENSMUSG00000032913


Mus musculus

Features
Gene ID: ENSMUSG00000032913
  
Biological name :Lrig2
  
Synonyms : leucine-rich repeats and immunoglobulin-like domains 2 / Lrig2 / Q52KR2
  
Possible biological names infered from orthology : O94898
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 104396418
Gene end: 104511918
  
Corresponding Affymetrix probe sets: 10500876 (MoGene1.0st)   1455217_at (Mouse Genome 430 2.0 Array)   1460025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142540
Ensembl peptide - ENSMUSP00000143406
Ensembl peptide - ENSMUSP00000035999
Ensembl peptide - ENSMUSP00000142373
NCBI entrez gene - 269473     See in Manteia.
MGI - MGI:2443718
RefSeq - XM_006501544
RefSeq - XM_017319602
RefSeq - NM_001025067
RefSeq - NM_001310698
RefSeq Peptide - NP_001020238
RefSeq Peptide - NP_001297627
swissprot - Q52KR2
swissprot - B2RRI5
swissprot - A0A0G2JG33
Ensembl - ENSMUSG00000032913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrig2ENSDARG00000078561Danio rerio
 LRIG2ENSGALG00000001733Gallus gallus
 LRIG2ENSG00000198799Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrig3 / Q6P1C6 / Leucine-rich repeats and immunoglobulin-like domains protein 3 / Q6UXM1* / leucine rich repeats and immunoglobulin like domains 3*ENSMUSG0000002010555
Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*ENSMUSG0000003002948
Adgra2 / Q91ZV8 / Adhesion G protein-coupled receptor A2 / Q96PE1*ENSMUSG0000003148617
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*ENSMUSG0000002909016
Vasn / Q9CZT5 / vasorin / Q6EMK4*ENSMUSG0000003964614
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*ENSMUSG0000003359512
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*ENSMUSG0000006724210
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*ENSMUSG0000003925210
Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*ENSMUSG0000003656010
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*ENSMUSG000000254757


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0010640 regulation of platelet-derived growth factor receptor signaling pathway IGI
 biological_processGO:0010977 negative regulation of neuron projection development IGI
 biological_processGO:0048679 regulation of axon regeneration IGI
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IMP
 biological_processGO:0060384 innervation IGI
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 biological_processGO:2001222 regulation of neuron migration IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0097708 intracellular vesicle IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1+,Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2+
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1+,Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1+,Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1+,Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2+
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lrig2tm1.1Hhed/Lrig2tm1.1Hhed
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1+,Lrig3tm1.1Good/Lrig3tm1.1Good
Genetic Background: B6N.Cg-Lrig1Gt(GST4169C6)Lex Lrig3tm1.1Good

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2Gt(RST656)Byg
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

Allelic Composition: Lrig1Gt(GST4169C6)Lex/Lrig1Gt(GST4169C6)Lex,Lrig2Gt(RST656)Byg/Lrig2+
Genetic Background: B6N.129-Lrig2Gt(RST656)Byg Lrig1Gt(GST4169C6)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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