ENSMUSG00000036560


Mus musculus

Features
Gene ID: ENSMUSG00000036560
  
Biological name :Lgi4
  
Synonyms : Leucine-rich repeat LGI family member 4 / Lgi4 / Q8K1S1
  
Possible biological names infered from orthology : Q8N135
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B1
Gene start: 31059342
Gene end: 31070935
  
Corresponding Affymetrix probe sets: 10552075 (MoGene1.0st)   1434121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146008
Ensembl peptide - ENSMUSP00000041579
Ensembl peptide - ENSMUSP00000125865
Ensembl peptide - ENSMUSP00000145660
NCBI entrez gene - 243914     See in Manteia.
MGI - MGI:2180197
RefSeq - XM_006539960
RefSeq - NM_144556
RefSeq - XM_006539958
RefSeq - XM_006539959
RefSeq Peptide - NP_653139
swissprot - Q8K1S1
swissprot - F7CXY1
swissprot - A0A0U1RPJ8
swissprot - A0A0U1RNQ3
Ensembl - ENSMUSG00000036560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgi1aENSDARG00000020493Danio rerio
 lgi1bENSDARG00000058421Danio rerio
 LGI4ENSG00000153902Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*ENSMUSG0000006724248
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*ENSMUSG0000003359542
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*ENSMUSG0000003925238
Lrig2 / Q52KR2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898*ENSMUSG0000003291320
Lrig3 / Q6P1C6 / Leucine-rich repeats and immunoglobulin-like domains protein 3 / Q6UXM1* / leucine rich repeats and immunoglobulin like domains 3*ENSMUSG0000002010519
Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*ENSMUSG0000003002918
Adgra2 / Q91ZV8 / Adhesion G protein-coupled receptor A2 / Q96PE1*ENSMUSG0000003148616
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*ENSMUSG0000002909015
Vasn / Q9CZT5 / vasorin / Q6EMK4*ENSMUSG0000003964614
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*ENSMUSG000000254757


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005492  Leucine-rich glioma-inactivated , EPTP repeat
 IPR009039  EAR
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0014009 glial cell proliferation IDA
 biological_processGO:0014044 Schwann cell development IMP
 biological_processGO:0021782 glial cell development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IMP
 biological_processGO:0031641 regulation of myelination IEA
 biological_processGO:0042063 gliogenesis IMP
 biological_processGO:0042551 neuron maturation IMP
 biological_processGO:0042552 myelination IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Lgi4clp/Lgi4clp
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lgi4clp/Lgi4clp
Genetic Background: involves: C57BL/6J

Allelic Composition: Lgi4tm1.1Jrb/Lgi4tm1.1Jrb,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001105 abnormal PNS glia "malformation or absence of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0008155 decreased diameter of radius "reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0008157 decreased diameter of ulna "reduced width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Adam22tm1Sag/Adam22tm1Sag,Lgi4tm1Sjm/Lgi4tm1Sjm
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040537 Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*  / reaction / complex
 ENSMUSG00000020926 Adam11 / Q9R1V4 / Disintegrin and metalloproteinase domain-containing protein 11 / O75078* / ADAM metallopeptidase domain 11*  / complex / reaction
 ENSMUSG00000025964 Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*  / reaction / complex






 

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