ENSDARG00000020493


Danio rerio

Features
Gene ID: ENSDARG00000020493
  
Biological name :lgi1a
  
Synonyms : leucine-rich, glioma inactivated 1a / lgi1a
  
Possible biological names infered from orthology : leucine rich repeat LGI family member 4 / LGI4 / Q8K1S1 / Q8N135
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 421231
Gene end: 430143
  
Corresponding Affymetrix probe sets: Dr.1612.1.A1_at (Zebrafish Array)   NM_199627_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000027521
Ensembl peptide - ENSDARP00000154846
NCBI entrez gene - 323011     See in Manteia.
RefSeq - NM_199627
RefSeq Peptide - NP_955921
swissprot - Q2HPG2
swissprot - Q6P0D2
ZFIN ID - ZDB-GENE-030131-1731
Ensembl - ENSDARG00000020493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGI4ENSG00000153902Homo sapiens
 Lgi4ENSMUSG00000036560Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lgi1b / leucine-rich, glioma inactivated 1b / LGI4* / Q8K1S1* / Q8N135* / leucine rich repeat LGI family member 4*ENSDARG0000005842176
lgi3 / leucine-rich repeat LGI family, member 3 / Q8K406* / Q8N145*ENSDARG0000004135853
lgi2a / leucine-rich repeat LGI family, member 2a / LGI2* / Q8N0V4* / leucine rich repeat LGI family member 2*ENSDARG0000011106950
lgi2b / leucine-rich repeat LGI family, member 2b / LGI2* / Q8K4Z0* / Q8N0V4* / leucine rich repeat LGI family member 2*ENSDARG0000006970145
lrig1 / leucine-rich repeats and immunoglobulin-like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *ENSDARG0000007562518
lrig2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898* / Q52KR2*ENSDARG0000007856116
adgra2 / E7FBY6 / adhesion G protein-coupled receptor A2 / Q91ZV8* / Q96PE1*ENSDARG0000007699415
vasnb / vasorin b / VASN* / Q9CZT5* / Q6EMK4* / vasorin*ENSDARG0000010256512
vasna / vasorin a / VASN* / Q6EMK4* / vasorin*ENSDARG0000009926612
adgra3 / adhesion G protein-coupled receptor A3 / Q8IWK6*ENSDARG000000736738
adgra1a / adhesion G protein-coupled receptor A1aENSDARG000000541776


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005492  Leucine-rich glioma-inactivated , EPTP repeat
 IPR009039  EAR
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0042552 myelination IDA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003824 catalytic activity IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain cell decreased amount , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0001261 ventricular system ventricular system increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000079204 adam11 / ADAM metallopeptidase domain 11 / O75078* / Q9R1V4* / Disintegrin and metalloproteinase domain-containing protein 11 *  / reaction / complex
 ENSDARG00000060532 adam22 / ADAM metallopeptidase domain 22 / Q9P0K1* / Q9R1V6* / Disintegrin and metalloproteinase domain-containing protein 22 *  / complex / reaction






 

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