Manteia - Molecule gene

ENSMUSG00000020105

Mus musculus

Features

Gene ID:	ENSMUSG00000020105

Biological name :	Lrig3

Synonyms :	Leucine-rich repeats and immunoglobulin-like domains protein 3 / Lrig3 / Q6P1C6

Possible biological names infered from orthology :	leucine rich repeats and immunoglobulin like domains 3 / Q6UXM1

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	D3
Gene start:	125966168
Gene end:	126015359

Corresponding Affymetrix probe sets:	10366746 (MoGene1.0st) 1429368_at (Mouse Genome 430 2.0 Array) 1430554_at (Mouse Genome 430 2.0 Array) 1430555_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000074360 NCBI entrez gene - 320398 See in Manteia. MGI - MGI:2443955 RefSeq - NM_177152 RefSeq Peptide - NP_796126 swissprot - Q6P1C6 Ensembl - ENSMUSG00000020105

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
LRIG3	ENSGALG00000009755	Gallus gallus
LRIG3	ENSG00000139263	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lrig2 / Q52KR2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898*	ENSMUSG00000032913	52
Lrig1 / P70193 / Leucine-rich repeats and immunoglobulin-like domains protein 1 / Q96JA1* / leucine rich repeats and immunoglobulin like domains 1*	ENSMUSG00000030029	49
Adgra2 / Q91ZV8 / Adhesion G protein-coupled receptor A2 / Q96PE1*	ENSMUSG00000031486	17
Adgra3 / Q7TT36 / Adhesion G protein-coupled receptor A3 / Q8IWK6*	ENSMUSG00000029090	15
Vasn / Q9CZT5 / vasorin / Q6EMK4*	ENSMUSG00000039646	13
Lgi3 / Q8K406 / Leucine-rich repeat LGI family member 3 / Q8N145*	ENSMUSG00000033595	11
Lgi1 / Q9JIA1 / Leucine-rich glioma-inactivated protein 1 / O95970* / leucine rich glioma inactivated 1*	ENSMUSG00000067242	10
Lgi2 / Q8K4Z0 / Leucine-rich repeat LGI family member 2 / Q8N0V4*	ENSMUSG00000039252	9
Lgi4 / Q8K1S1 / Leucine-rich repeat LGI family member 4 / Q8N135*	ENSMUSG00000036560	9
Adgra1 / Q8C4G9 / Adhesion G protein-coupled receptor A1 / Q86SQ6*	ENSMUSG00000025475	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000483	Cysteine-rich flanking region, C-terminal
IPR001611	Leucine-rich repeat
IPR003591	Leucine-rich repeat, typical subtype
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013098	Immunoglobulin I-set
IPR013783	Immunoglobulin-like fold
IPR032675	Leucine-rich repeat domain superfamily
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0032474	otolith morphogenesis	IGI
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030659	cytoplasmic vesicle membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000037	abnormal lateral semicircular canal	"anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: involves: BALB/cJ Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1⁺,Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig3^tm1.1Good
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: involves: BALB/cJ
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Washc1^tm1Xya/Washc1^tm1Xya Genetic Background: involves: 129
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002842	increased blood pressure	"increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0002858	abnormal posterior semicircular canal	"anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0003162	reduced size of lateral semicircular canal		Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003164	reduced size of posterior semicircular canal		Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good Allelic Composition: Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig3^tm1.1Good
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003442	decreased circulating glycerol level	"lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0003938	abnormal ear development	"developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004425	abnormal otolith organ	"any structural abnormality in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lbr^ic-J/Lbr^ic-J Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0011238	abnormal inner ear development	"atypical initial production, differentiation, migration or maturation of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:llw2]	Show Allelic Composition: Lrig1^{Gt(GST4169C6)Lex}/Lrig1^{Gt(GST4169C6)Lex},Lrig3^tm1.1Good/Lrig3^tm1.1Good Genetic Background: B6N.Cg-Lrig1^{Gt(GST4169C6)Lex} Lrig3^tm1.1Good
MP:0011952	decreased cardiac stroke volume	"reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J
MP:0020204	abnormal heart left ventricle weight	"anomaly in the average weight of the left ventricle compared to the control" [GOC:NV]	Show Allelic Composition: Des^tm1Cba/Des^tm1Cba Genetic Background: involves: 129S2/SvPas * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr