ENSG00000020181


Homo sapiens

Features
Gene ID: ENSG00000020181
  
Biological name :ADGRA2
  
Synonyms : ADGRA2 / adhesion G protein-coupled receptor A2 / Q96PE1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p11.23
Gene start: 37784191
Gene end: 37844896
  
Corresponding Affymetrix probe sets: 221814_at (Human Genome U133 Plus 2.0 Array)   65718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000323508
Ensembl peptide - ENSP00000400860
Ensembl peptide - ENSP00000406367
NCBI entrez gene - 25960     See in Manteia.
OMIM - 606823
RefSeq - XM_011544483
RefSeq - NM_032777
RefSeq - XM_005273471
RefSeq - XM_011544481
RefSeq - XM_011544482
RefSeq Peptide - NP_116166
swissprot - Q96PE1
swissprot - H7C1L1
Ensembl - ENSG00000020181
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgra2ENSDARG00000076994Danio rerio
 ADGRA2ENSGALG00000003118Gallus gallus
 Adgra2ENSMUSG00000031486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADGRA3 / Q8IWK6 / adhesion G protein-coupled receptor A3ENSG0000015299043
ADGRA1 / Q86SQ6 / adhesion G protein-coupled receptor A1ENSG0000019717716
LRIG3 / Q6UXM1 / leucine rich repeats and immunoglobulin like domains 3ENSG0000013926314
LRIG2 / O94898 / leucine rich repeats and immunoglobulin like domains 2ENSG0000019879913
LRIG1 / Q96JA1 / leucine rich repeats and immunoglobulin like domains 1ENSG0000014474913
VASN / Q6EMK4 / vasorinENSG000001681409
LGI3 / Q8N145 / leucine rich repeat LGI family member 3ENSG000001684817
LGI4 / Q8N135 / leucine rich repeat LGI family member 4ENSG000001539027
LGI2 / Q8N0V4 / leucine rich repeat LGI family member 2ENSG000001530126
LGI1 / O95970 / leucine rich glioma inactivated 1ENSG000001082316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000832  GPCR, family 2, secretin-like
 IPR001611  Leucine-rich repeat
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0043542 endothelial cell migration IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0050920 regulation of chemotaxis IEA
 biological_processGO:0090210 regulation of establishment of blood-brain barrier IEA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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