ENSG00000144749


Homo sapiens

Features
Gene ID: ENSG00000144749
  
Biological name :LRIG1
  
Synonyms : leucine rich repeats and immunoglobulin like domains 1 / LRIG1 / Q96JA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.1
Gene start: 66378797
Gene end: 66501263
  
Corresponding Affymetrix probe sets: 211596_s_at (Human Genome U133 Plus 2.0 Array)   236173_s_at (Human Genome U133 Plus 2.0 Array)   238339_x_at (Human Genome U133 Plus 2.0 Array)   240140_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000273261
Ensembl peptide - ENSP00000373208
NCBI entrez gene - 26018     See in Manteia.
OMIM - 608868
RefSeq - XM_017006136
RefSeq - NM_015541
RefSeq - XM_017006134
RefSeq - XM_017006135
RefSeq - XM_011533578
RefSeq - XM_011533579
RefSeq Peptide - NP_056356
swissprot - Q96JA1
Ensembl - ENSG00000144749
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrig1ENSDARG00000075625Danio rerio
 LRIG1ENSGALG00000007483Gallus gallus
 Lrig1ENSMUSG00000030029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRIG3 / Q6UXM1 / leucine rich repeats and immunoglobulin like domains 3ENSG0000013926349
LRIG2 / O94898 / leucine rich repeats and immunoglobulin like domains 2ENSG0000019879947
ADGRA2 / Q96PE1 / adhesion G protein-coupled receptor A2ENSG0000002018116
ADGRA3 / Q8IWK6 / adhesion G protein-coupled receptor A3ENSG0000015299015
VASN / Q6EMK4 / vasorinENSG0000016814014
LGI3 / Q8N145 / leucine rich repeat LGI family member 3ENSG0000016848111
LGI1 / O95970 / leucine rich glioma inactivated 1ENSG0000010823110
LGI2 / Q8N0V4 / leucine rich repeat LGI family member 2ENSG000001530129
LGI4 / Q8N135 / leucine rich repeat LGI family member 4ENSG000001539028
ADGRA1 / Q86SQ6 / adhesion G protein-coupled receptor A1ENSG000001971777


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0022405 hair cycle process IEA
 biological_processGO:0032474 otolith morphogenesis IEA
 biological_processGO:0060384 innervation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by EGFR
Negative regulation of MET activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / reaction
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex






 

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