ENSG00000168481


Homo sapiens

Features
Gene ID: ENSG00000168481
  
Biological name :LGI3
  
Synonyms : leucine rich repeat LGI family member 3 / LGI3 / Q8N145
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 22146825
Gene end: 22157084
  
Corresponding Affymetrix probe sets: 238061_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399121
Ensembl peptide - ENSP00000430653
Ensembl peptide - ENSP00000427817
Ensembl peptide - ENSP00000302297
NCBI entrez gene - 203190     See in Manteia.
OMIM - 608302
RefSeq - NM_139278
RefSeq Peptide - NP_644807
swissprot - E5RIV5
swissprot - H0YAP4
swissprot - Q8N145
Ensembl - ENSG00000168481
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgi3ENSDARG00000041358Danio rerio
 Lgi3ENSMUSG00000033595Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGI1 / O95970 / leucine rich glioma inactivated 1ENSG0000010823151
LGI2 / Q8N0V4 / leucine rich repeat LGI family member 2ENSG0000015301250
LGI4 / Q8N135 / leucine rich repeat LGI family member 4ENSG0000015390241
LRIG2 / O94898 / leucine rich repeats and immunoglobulin like domains 2ENSG0000019879923
LRIG3 / Q6UXM1 / leucine rich repeats and immunoglobulin like domains 3ENSG0000013926322
LRIG1 / Q96JA1 / leucine rich repeats and immunoglobulin like domains 1ENSG0000014474921
ADGRA2 / Q96PE1 / adhesion G protein-coupled receptor A2ENSG0000002018118
ADGRA3 / Q8IWK6 / adhesion G protein-coupled receptor A3ENSG0000015299016
VASN / Q6EMK4 / vasorinENSG0000016814014
ADGRA1 / Q86SQ6 / adhesion G protein-coupled receptor A1ENSG000001971779


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005492  Leucine-rich glioma-inactivated , EPTP repeat
 IPR009039  EAR
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099365 STX1B / P61266 / syntaxin 1B  / complex / reaction
 ENSG00000106089 STX1A / Q16623 / syntaxin 1A  / complex / reaction
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / complex / reaction
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / reaction / complex






 

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