ENSG00000153012


Homo sapiens

Features
Gene ID: ENSG00000153012
  
Biological name :LGI2
  
Synonyms : leucine rich repeat LGI family member 2 / LGI2 / Q8N0V4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p15.2
Gene start: 24998847
Gene end: 25030879
  
Corresponding Affymetrix probe sets: 219699_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371548
Ensembl peptide - ENSP00000426254
NCBI entrez gene - 55203     See in Manteia.
OMIM - 608301
RefSeq - XM_017008356
RefSeq - NM_018176
RefSeq - XM_011513850
RefSeq Peptide - NP_060646
swissprot - Q8N0V4
swissprot - H0YA65
Ensembl - ENSG00000153012
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgi2aENSDARG00000111069Danio rerio
 lgi2bENSDARG00000069701Danio rerio
 LGI2ENSGALG00000043283Gallus gallus
 Lgi2ENSMUSG00000039252Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGI1 / O95970 / leucine rich glioma inactivated 1ENSG0000010823156
LGI3 / Q8N145 / leucine rich repeat LGI family member 3ENSG0000016848150
LGI4 / Q8N135 / leucine rich repeat LGI family member 4ENSG0000015390241
LRIG2 / O94898 / leucine rich repeats and immunoglobulin like domains 2ENSG0000019879920
LRIG3 / Q6UXM1 / leucine rich repeats and immunoglobulin like domains 3ENSG0000013926319
LRIG1 / Q96JA1 / leucine rich repeats and immunoglobulin like domains 1ENSG0000014474918
ADGRA2 / Q96PE1 / adhesion G protein-coupled receptor A2ENSG0000002018116
ADGRA3 / Q8IWK6 / adhesion G protein-coupled receptor A3ENSG0000015299015
VASN / Q6EMK4 / vasorinENSG0000016814013
ADGRA1 / Q86SQ6 / adhesion G protein-coupled receptor A1ENSG000001971777


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR005492  Leucine-rich glioma-inactivated , EPTP repeat
 IPR009039  EAR
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
LGI-ADAM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114948 ADAM23 / O75077 / ADAM metallopeptidase domain 23  / reaction / complex
 ENSG00000008277 ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22  / reaction / complex






 

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