ENSMUSG00000020422


Mus musculus

Features
Gene ID: ENSMUSG00000020422
  
Biological name :Tns3
  
Synonyms : Q5SSZ5 / Tensin-3 / Tns3
  
Possible biological names infered from orthology : Q68CZ2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 8431652
Gene end: 8664535
  
Corresponding Affymetrix probe sets: 10384233 (MoGene1.0st)   1446636_at (Mouse Genome 430 2.0 Array)   1455333_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020695
NCBI entrez gene - 319939     See in Manteia.
MGI - MGI:2443012
RefSeq - XM_017314607
RefSeq - NM_001083587
RefSeq - XM_011243727
RefSeq - XM_011243728
RefSeq - XM_006514735
RefSeq - XM_006514740
RefSeq - XM_006514741
RefSeq Peptide - NP_001077056
swissprot - Q5SSZ5
Ensembl - ENSMUSG00000020422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tns3.2ENSDARG00000031911Danio rerio
 TNS3ENSGALG00000039139Gallus gallus
 TNS3ENSG00000136205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tns1 / tensin 1 / Q9HBL0*ENSMUSG0000005532246
Tns2 / Q8CGB6 / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q63HR2* / tensin 2*ENSMUSG0000003700335
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG0000001760716
Gak / cyclin-G-associated kinase isoform 3 / O14976* / cyclin G associated kinase*ENSMUSG0000006223413
Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*ENSMUSG0000002852813
Pten / O08586 / phosphatase and tensin homolog / P60484*ENSMUSG000000136637
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG000000314816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR035012  Tensin-like, SH2 domain
 IPR035892  C2 domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0048286 lung alveolus development IMP
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
Show

Allelic Composition: KitMhdasow3/Kit+
Genetic Background: C3HeB/FeJ-KitMhdasow3

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / complex / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / complex / reaction






 

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