ENSMUSG00000037003


Mus musculus

Features
Gene ID: ENSMUSG00000037003
  
Biological name :Tns2
  
Synonyms : Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q8CGB6 / Tns2
  
Possible biological names infered from orthology : Q63HR2 / tensin 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F2
Gene start: 102100413
Gene end: 102116401
  
Corresponding Affymetrix probe sets: 10427095 (MoGene1.0st)   1452264_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155309
Ensembl peptide - ENSMUSP00000129146
Ensembl peptide - ENSMUSP00000155624
Ensembl peptide - ENSMUSP00000155830
Ensembl peptide - ENSMUSP00000041087
NCBI entrez gene - 209039     See in Manteia.
MGI - MGI:2387586
RefSeq - XM_011245537
RefSeq - NM_001355636
RefSeq - NM_153533
RefSeq - XM_006520692
RefSeq - XM_006520693
RefSeq - XM_006520694
RefSeq - XM_006520691
RefSeq Peptide - NP_705761
RefSeq Peptide - NP_001342565
swissprot - Q8CGB6
Ensembl - ENSMUSG00000037003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tns2aENSDARG00000076292Danio rerio
 tns2bENSDARG00000068397Danio rerio
 TNS2ENSG00000111077Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tns1 / tensin 1 / Q9HBL0*ENSMUSG0000005532240
Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*ENSMUSG0000002042236
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG0000001760715
Gak / cyclin-G-associated kinase isoform 3 / O14976* / cyclin G associated kinase*ENSMUSG0000006223414
Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*ENSMUSG0000002852812
Pten / O08586 / phosphatase and tensin homolog / P60484*ENSMUSG000000136638
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG000000314817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR035012  Tensin-like, SH2 domain
 IPR035892  C2 domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0014850 response to muscle activity IMP
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0032963 collagen metabolic process IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048871 multicellular organismal homeostasis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr