ENSMUSG00000062234


Mus musculus

Features
Gene ID: ENSMUSG00000062234
  
Biological name :Gak
  
Synonyms : cyclin-G-associated kinase isoform 3 / Gak
  
Possible biological names infered from orthology : cyclin G associated kinase / O14976
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 108569411
Gene end: 108629755
  
Corresponding Affymetrix probe sets: 10532187 (MoGene1.0st)   1426703_at (Mouse Genome 430 2.0 Array)   1426704_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116862
Ensembl peptide - ENSMUSP00000143646
Ensembl peptide - ENSMUSP00000143359
Ensembl peptide - ENSMUSP00000142931
Ensembl peptide - ENSMUSP00000118713
Ensembl peptide - ENSMUSP00000118008
Ensembl peptide - ENSMUSP00000036705
Ensembl peptide - ENSMUSP00000115184
NCBI entrez gene - 231580     See in Manteia.
MGI - MGI:2442153
RefSeq - XM_017320853
RefSeq - NM_001282051
RefSeq - NM_001282052
RefSeq - NM_153569
RefSeq - XM_006534905
RefSeq - XM_006534907
RefSeq Peptide - NP_001268980
RefSeq Peptide - NP_705797
RefSeq Peptide - NP_001268981
swissprot - A0A0G2JFZ0
swissprot - A0A0G2JEW6
swissprot - F6SLK1
swissprot - A0A0R4J0F6
swissprot - F7BG02
swissprot - D6RHK5
swissprot - A0A0G2JGP6
Ensembl - ENSMUSG00000062234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gakENSDARG00000090654Danio rerio
 GAKENSGALG00000015352Gallus gallus
 GAKENSG00000178950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*ENSMUSG0000002852833
Tns1 / tensin 1 / Q9HBL0*ENSMUSG0000005532217
Tns2 / Q8CGB6 / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q63HR2* / tensin 2*ENSMUSG0000003700315
Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*ENSMUSG0000002042214
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG000000314819
Pten / O08586 / phosphatase and tensin homolog / P60484*ENSMUSG000000136637
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG000000176076


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001623  DnaJ domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IEA
 biological_processGO:0072318 clathrin coat disassembly IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090160 Golgi to lysosome transport IEA
 biological_processGO:1905224 clathrin-coated pit assembly IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0010900 abnormal pulmonary interalveolar septum morphology "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0010995 abnormal lung alveolus development "anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways" [GO:0048286]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc34a2tm1Sega/Slc34a2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6JJcl

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Fgf23tm1.1Kew/Fgf23+
Genetic Background: B6.129-Fgf23tm1.1Kew

 MP:0012242 abnormal hepatoblast differentiation "developmental anomaly or inability of hepatoblasts to differentiate into hepatocytes and cholangiocytes" [MGI:anna]
Show

Allelic Composition: Gaktm2Legr/Gaktm2Legr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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