ENSG00000178950


Homo sapiens

Features
Gene ID: ENSG00000178950
  
Biological name :GAK
  
Synonyms : cyclin G associated kinase / GAK / O14976
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p16.3
Gene start: 849276
Gene end: 932373
  
Corresponding Affymetrix probe sets: 202281_at (Human Genome U133 Plus 2.0 Array)   40225_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424553
Ensembl peptide - ENSP00000422391
Ensembl peptide - ENSP00000424701
Ensembl peptide - ENSP00000486984
Ensembl peptide - ENSP00000484475
Ensembl peptide - ENSP00000426908
Ensembl peptide - ENSP00000426728
Ensembl peptide - ENSP00000426062
Ensembl peptide - ENSP00000314499
Ensembl peptide - ENSP00000421049
Ensembl peptide - ENSP00000421361
Ensembl peptide - ENSP00000421814
NCBI entrez gene - 2580     See in Manteia.
OMIM - 602052
RefSeq - XM_017007995
RefSeq - XM_011513426
RefSeq - XM_011513427
RefSeq - XM_011513428
RefSeq - XM_011513429
RefSeq - XM_011513430
RefSeq - XM_011513431
RefSeq - XM_011513432
RefSeq - XM_011513434
RefSeq - XM_017007991
RefSeq - XM_017007992
RefSeq - XM_017007993
RefSeq - XM_017007994
RefSeq - NM_001318134
RefSeq - NM_005255
RefSeq - XM_005272268
RefSeq - XM_005272270
RefSeq - XM_011513425
RefSeq Peptide - NP_001305063
RefSeq Peptide - NP_005246
swissprot - D6RC24
swissprot - D6RAW3
swissprot - D6RAQ7
swissprot - H0Y8H5
swissprot - D6RF16
swissprot - H0YA39
swissprot - O14976
swissprot - A0A087X1U9
swissprot - H0Y9M4
swissprot - D6RE78
Ensembl - ENSG00000178950
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gakENSDARG00000090654Danio rerio
 GAKENSGALG00000015352Gallus gallus
 GakENSMUSG00000062234Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667534
TNS1 / Q9HBL0 / tensin 1ENSG0000007930816
TNS2 / Q63HR2 / tensin 2ENSG0000011107716
TNS3 / Q68CZ2 / tensin 3ENSG0000013620515
TPTE2 / Q6XPS3 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2ENSG000001329589
TPTE / P56180 / transmembrane phosphatase with tensin homologyENSG000002743918
PTEN / P60484 / phosphatase and tensin homologENSG000001718627
TNS4 / Q8IZW8 / tensin 4ENSG000001317466


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001623  DnaJ domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0007029 endoplasmic reticulum organization ISS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0016191 synaptic vesicle uncoating ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IMP
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding TAS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0072318 clathrin coat disassembly IMP
 biological_processGO:0072583 clathrin-dependent endocytosis IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090160 Golgi to lysosome transport IMP
 biological_processGO:1905224 clathrin-coated pit assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding ISS
 molecular_functionGO:0051087 chaperone binding TAS


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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